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Chronic kidney disease progression in elderly Iranian patients: a cohort study.

Shojamoradi MH, Saberi Isfeedvajani M, Mahdavi-Mazdeh M, Ahmadi F, Gatmiri SM, Abbasi Larki R - Nephrourol Mon (2014)

Bottom Line: Two thirds of the patients were older than 60 years.Younger ones showed more rapid decline in their eGFR, while older patients had more stable renal function.It seems necessary to conduct more researches in order to redefine CKD and identify its prognostic markers in elderly population.

View Article: PubMed Central - PubMed

Affiliation: Nephrology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: In the past few decades, Chronic Kidney Disease (CKD) - a disease with progressive decline in renal function - has become an important problem of global public health, not only in developed countries, but also in developing countries with less economic power.

Objectives: In this study, CKD progression to death or End Stage Renal Disease (ESRD) in elderly Iranian patients was compared with younger counterparts.

Patients and methods: This retrospective cohort study was conducted on CKD patients with estimated Glomerular Filtration Rate (eGFR) < 60 mL/min, in a nephrology clinic in Tehran from December of 2006 until December of 2012. eGFR trend, death and need to renal replacement therapy (RRT) were evaluated as outcomes and compared between patients younger and older than 60 years. Data were analyzed using SPSS version 13.

Results: Five-hundred and two patients were enrolled and followed up for an average of 37.6 months. Two thirds of the patients were older than 60 years. The incidence density of ESRD in patients younger and older than 60 years were 6.3 and 3.6 for 100 persons per year, respectively. Younger ones showed more rapid decline in their eGFR, while older patients had more stable renal function.

Conclusions: It seems necessary to conduct more researches in order to redefine CKD and identify its prognostic markers in elderly population.

No MeSH data available.


Related in: MedlinePlus

The Incidence Density of Death and RRT by Age Groups of the Patients
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fig13244: The Incidence Density of Death and RRT by Age Groups of the Patients

Mentions: The patients were followed for an average of 37.6 months. During this period, 15 patients with stage 3 or 4 of CKD died; of which 2 patients were younger than 60, 5 patients were between 60 and 75 years and 8 were older than 75 years. Table 2 shows the incidence density of death and RRT based on age group and CKD stage. The incidence density of death was 0.98 (0.6-1.6; CI 95%) for 100 person years. The incidence density of death in patients younger and older than 60 years was 0.34 (0.08-1.3 CI 95%) and 1.4 (0.8-2.3 CI 95%) for 100 person-years, respectively. During the study period, 71 patients with stage 3 or 4 of CKD required RRT and the incidence density of RRT was 4.6 (3.6-5.8 CI 95%) for 100 person-years. The incidence density of RRT in patients older than 60 years was 3.6 (2.5-5 CI 95%) for 100 person-years. The incidence density of RRT in younger patients was 6.3 (4.5-8.6 CI 95%) for 100 person-years, which was about two times more than older counterparts. Figure 1 compares the incidence density of death and RRT according to the age group of the patients.


Chronic kidney disease progression in elderly Iranian patients: a cohort study.

Shojamoradi MH, Saberi Isfeedvajani M, Mahdavi-Mazdeh M, Ahmadi F, Gatmiri SM, Abbasi Larki R - Nephrourol Mon (2014)

The Incidence Density of Death and RRT by Age Groups of the Patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318018&req=5

fig13244: The Incidence Density of Death and RRT by Age Groups of the Patients
Mentions: The patients were followed for an average of 37.6 months. During this period, 15 patients with stage 3 or 4 of CKD died; of which 2 patients were younger than 60, 5 patients were between 60 and 75 years and 8 were older than 75 years. Table 2 shows the incidence density of death and RRT based on age group and CKD stage. The incidence density of death was 0.98 (0.6-1.6; CI 95%) for 100 person years. The incidence density of death in patients younger and older than 60 years was 0.34 (0.08-1.3 CI 95%) and 1.4 (0.8-2.3 CI 95%) for 100 person-years, respectively. During the study period, 71 patients with stage 3 or 4 of CKD required RRT and the incidence density of RRT was 4.6 (3.6-5.8 CI 95%) for 100 person-years. The incidence density of RRT in patients older than 60 years was 3.6 (2.5-5 CI 95%) for 100 person-years. The incidence density of RRT in younger patients was 6.3 (4.5-8.6 CI 95%) for 100 person-years, which was about two times more than older counterparts. Figure 1 compares the incidence density of death and RRT according to the age group of the patients.

Bottom Line: Two thirds of the patients were older than 60 years.Younger ones showed more rapid decline in their eGFR, while older patients had more stable renal function.It seems necessary to conduct more researches in order to redefine CKD and identify its prognostic markers in elderly population.

View Article: PubMed Central - PubMed

Affiliation: Nephrology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: In the past few decades, Chronic Kidney Disease (CKD) - a disease with progressive decline in renal function - has become an important problem of global public health, not only in developed countries, but also in developing countries with less economic power.

Objectives: In this study, CKD progression to death or End Stage Renal Disease (ESRD) in elderly Iranian patients was compared with younger counterparts.

Patients and methods: This retrospective cohort study was conducted on CKD patients with estimated Glomerular Filtration Rate (eGFR) < 60 mL/min, in a nephrology clinic in Tehran from December of 2006 until December of 2012. eGFR trend, death and need to renal replacement therapy (RRT) were evaluated as outcomes and compared between patients younger and older than 60 years. Data were analyzed using SPSS version 13.

Results: Five-hundred and two patients were enrolled and followed up for an average of 37.6 months. Two thirds of the patients were older than 60 years. The incidence density of ESRD in patients younger and older than 60 years were 6.3 and 3.6 for 100 persons per year, respectively. Younger ones showed more rapid decline in their eGFR, while older patients had more stable renal function.

Conclusions: It seems necessary to conduct more researches in order to redefine CKD and identify its prognostic markers in elderly population.

No MeSH data available.


Related in: MedlinePlus