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Extramedullary hematopoiesis presenting as a right adrenal mass in a patient with Beta thalassemia.

Karami H, Kosaryan M, Taghipour M, Sharifian R, Aliasgharian A, Motalebi M - Nephrourol Mon (2014)

Bottom Line: Extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma.Results of biochemical evaluations were insignificant.To the best of our knowledge, we document the first reported case of adrenal extramedullary hematopoiesis in Iran, which seems to be rare and remarkable.

View Article: PubMed Central - PubMed

Affiliation: Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran.

ABSTRACT

Introduction: Extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma. It usually occurs in patients with hematologic disorder such as thalassemia.

Case presentation: The patient was a 23-year-old Iranian man with beta thalassemia who was admitted with a suprarenal mass. Adrenal mass was detected by ultrasonography and computed tomography. Results of biochemical evaluations were insignificant. The patient underwent right adrenalectomy. Gross and microscopic histopathologic examination demonstrated extramedullary hematopoiesis without any adrenal tissue.

Conclusions: To the best of our knowledge, we document the first reported case of adrenal extramedullary hematopoiesis in Iran, which seems to be rare and remarkable.

No MeSH data available.


Related in: MedlinePlus

A Bulky Mass in the Region of Right Kidney, Containing Necrotic and Calcified Areas, Is Visible in Above Computed Tomography Images
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fig13285: A Bulky Mass in the Region of Right Kidney, Containing Necrotic and Calcified Areas, Is Visible in Above Computed Tomography Images

Mentions: The patient was a 23-year-old Iranian man with beta thalassemia who was admitted with a suprarenal mass. Adrenal mass was detected by ultrasonography (US) and computed tomography (CT). Liver size was normal and without a bulky mass in US. A heterogeneous mass was observed in the superior part of the right kidney with scattered echogenic areas, suggesting small scattered calcification and internal cystic areas. Spleen size was 150 mm without mass. Contrast-enhanced spiral CT images showed 10 × 12 cm bulky mass in the right kidney region, containing necrotic and calcified areas. The borders of the lesion were clear and regular and no edema was seen in surrounding fat (Figure 1). Liver and spleen were enlarged but adenopathy and ascites were not observed. Results of biochemical evaluations were insignificant. The patient underwent right adrenalectomy. The resected mass weighed about 370 g. In the histopathologic study, the tissue was brown fragile and homogenous. Gross and microscopic examination demonstrated EMH. In histopathologic examination of the liver, stage I, grade II chronic hepatitis and hemochromatosis were reported. Hepatic sample was tested for hepatitis C virus genotypes 1a, 1b, 2, and 3a that yielded nontypable genotype; the reason could be low number of virus copy in the serum or presence of genotypes (subtypes) other than tested ones. The results of hepatitis C virus RNA loading test was negative. The complications of the patient’s disease were under control.


Extramedullary hematopoiesis presenting as a right adrenal mass in a patient with Beta thalassemia.

Karami H, Kosaryan M, Taghipour M, Sharifian R, Aliasgharian A, Motalebi M - Nephrourol Mon (2014)

A Bulky Mass in the Region of Right Kidney, Containing Necrotic and Calcified Areas, Is Visible in Above Computed Tomography Images
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318012&req=5

fig13285: A Bulky Mass in the Region of Right Kidney, Containing Necrotic and Calcified Areas, Is Visible in Above Computed Tomography Images
Mentions: The patient was a 23-year-old Iranian man with beta thalassemia who was admitted with a suprarenal mass. Adrenal mass was detected by ultrasonography (US) and computed tomography (CT). Liver size was normal and without a bulky mass in US. A heterogeneous mass was observed in the superior part of the right kidney with scattered echogenic areas, suggesting small scattered calcification and internal cystic areas. Spleen size was 150 mm without mass. Contrast-enhanced spiral CT images showed 10 × 12 cm bulky mass in the right kidney region, containing necrotic and calcified areas. The borders of the lesion were clear and regular and no edema was seen in surrounding fat (Figure 1). Liver and spleen were enlarged but adenopathy and ascites were not observed. Results of biochemical evaluations were insignificant. The patient underwent right adrenalectomy. The resected mass weighed about 370 g. In the histopathologic study, the tissue was brown fragile and homogenous. Gross and microscopic examination demonstrated EMH. In histopathologic examination of the liver, stage I, grade II chronic hepatitis and hemochromatosis were reported. Hepatic sample was tested for hepatitis C virus genotypes 1a, 1b, 2, and 3a that yielded nontypable genotype; the reason could be low number of virus copy in the serum or presence of genotypes (subtypes) other than tested ones. The results of hepatitis C virus RNA loading test was negative. The complications of the patient’s disease were under control.

Bottom Line: Extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma.Results of biochemical evaluations were insignificant.To the best of our knowledge, we document the first reported case of adrenal extramedullary hematopoiesis in Iran, which seems to be rare and remarkable.

View Article: PubMed Central - PubMed

Affiliation: Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran.

ABSTRACT

Introduction: Extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma. It usually occurs in patients with hematologic disorder such as thalassemia.

Case presentation: The patient was a 23-year-old Iranian man with beta thalassemia who was admitted with a suprarenal mass. Adrenal mass was detected by ultrasonography and computed tomography. Results of biochemical evaluations were insignificant. The patient underwent right adrenalectomy. Gross and microscopic histopathologic examination demonstrated extramedullary hematopoiesis without any adrenal tissue.

Conclusions: To the best of our knowledge, we document the first reported case of adrenal extramedullary hematopoiesis in Iran, which seems to be rare and remarkable.

No MeSH data available.


Related in: MedlinePlus