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Caffeic acid derivatives from Bupleurum chinense.

Haghi G, Hatami A, Mehran M, Hosseini H - Res Pharm Sci (2014 Sep-Oct)

Bottom Line: In addition, the flavonoid aglycones were characterized and quantified after acid hydrolysis of the plant material.The flavonols profile showed quercetin (0.36 g per 100 g), kaempferol (1.11 g per 100 g) and isorhamnetin (0.16 g per 100 g).Total phenolic and total flavonoid contents ranged from 7.3 to 18.7% and 0.58 to 2.72% in dry plant material, respectively.

View Article: PubMed Central - PubMed

Affiliation: Phytochemistry Group, Barij Essence Medicinal Plants Research Center, Kashan, I.R. Iran.

ABSTRACT
In this study, caffeic acid (CA) and its three derivatives including 3-caffeoylquinic acid (3-CQA, neochlorogenic acid), 4-caffeoylquinic acid (4-CQA, cryptochlorogenic acid), and 5-caffeoylquinic acid (5-CQA, chlorogenic acid) were identified in Bupleurum chinense aerial parts using reverse-phase high-performance liquid chromatography (RP-HPLC) with photodiode array (PDA) detector, reference compounds and chemical reactions. Separation was performed on a C18 column using gradient elution with 4% (v/v) aqueous acetic acid and acetonitrile as mobile phase at ambient temperature. In addition, the flavonoid aglycones were characterized and quantified after acid hydrolysis of the plant material. The flavonols profile showed quercetin (0.36 g per 100 g), kaempferol (1.11 g per 100 g) and isorhamnetin (0.16 g per 100 g). Total phenolic and total flavonoid contents ranged from 7.3 to 18.7% and 0.58 to 2.72% in dry plant material, respectively.

No MeSH data available.


Related in: MedlinePlus

Structure of caffeic acid and its derivatives (IUPAC numbering).
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Figure 1: Structure of caffeic acid and its derivatives (IUPAC numbering).

Mentions: A literature survey revealed that there is no report about the presence of CA and its derivatives in genus Bupleurum and other genera of Umbeliferae family except the occurrence of 1-O-caffeoylglycerol and ethyl caffeate in B. chinense aerial parts (2627). This study elucidates the occurrence of CA and its derivatives for the first time and three known flavonols in the aerial parts of B. chinense using several techniques. The chemical structures of CA and its derivatives has been shown in Fig. 1.


Caffeic acid derivatives from Bupleurum chinense.

Haghi G, Hatami A, Mehran M, Hosseini H - Res Pharm Sci (2014 Sep-Oct)

Structure of caffeic acid and its derivatives (IUPAC numbering).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318000&req=5

Figure 1: Structure of caffeic acid and its derivatives (IUPAC numbering).
Mentions: A literature survey revealed that there is no report about the presence of CA and its derivatives in genus Bupleurum and other genera of Umbeliferae family except the occurrence of 1-O-caffeoylglycerol and ethyl caffeate in B. chinense aerial parts (2627). This study elucidates the occurrence of CA and its derivatives for the first time and three known flavonols in the aerial parts of B. chinense using several techniques. The chemical structures of CA and its derivatives has been shown in Fig. 1.

Bottom Line: In addition, the flavonoid aglycones were characterized and quantified after acid hydrolysis of the plant material.The flavonols profile showed quercetin (0.36 g per 100 g), kaempferol (1.11 g per 100 g) and isorhamnetin (0.16 g per 100 g).Total phenolic and total flavonoid contents ranged from 7.3 to 18.7% and 0.58 to 2.72% in dry plant material, respectively.

View Article: PubMed Central - PubMed

Affiliation: Phytochemistry Group, Barij Essence Medicinal Plants Research Center, Kashan, I.R. Iran.

ABSTRACT
In this study, caffeic acid (CA) and its three derivatives including 3-caffeoylquinic acid (3-CQA, neochlorogenic acid), 4-caffeoylquinic acid (4-CQA, cryptochlorogenic acid), and 5-caffeoylquinic acid (5-CQA, chlorogenic acid) were identified in Bupleurum chinense aerial parts using reverse-phase high-performance liquid chromatography (RP-HPLC) with photodiode array (PDA) detector, reference compounds and chemical reactions. Separation was performed on a C18 column using gradient elution with 4% (v/v) aqueous acetic acid and acetonitrile as mobile phase at ambient temperature. In addition, the flavonoid aglycones were characterized and quantified after acid hydrolysis of the plant material. The flavonols profile showed quercetin (0.36 g per 100 g), kaempferol (1.11 g per 100 g) and isorhamnetin (0.16 g per 100 g). Total phenolic and total flavonoid contents ranged from 7.3 to 18.7% and 0.58 to 2.72% in dry plant material, respectively.

No MeSH data available.


Related in: MedlinePlus