Limits...
Preparation, characterization and optimization of glipizide controlled release nanoparticles.

Emami J, Boushehri MS, Varshosaz J - Res Pharm Sci (2014 Sep-Oct)

Bottom Line: The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide.The particle and release characteristics can be efficiently optimized using the Box-Behnken design.Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, I.R. Iran.

ABSTRACT
The purpose of the present study was to develop glipizide controlled release nanoparticles using alginate and chitosan thorough ionotropic controlled gelation method. Glipizide is a frequently prescribed second generation sulfonylurea which lowers the blood glucose in type-two diabetics. Quick absorption of the drug from the gastrointestinal tract along with short half- life of elimination makes it a good candidate for controlled release formulations. Alginate-chitosan nanoparticles (ACNP) are convenient controlled delivery systems for glipizide, due to both the release limiting properties of the system, and the bioadhesive nature of the polymers. In the present study, glipizide loaded alginate-chitosan nanoparticles (GlACNP) were prepared, and the particle characteristics including particle size (PS), zeta potential (ZP), entrapment efficiency (EE%), loading percent (LP), and mean release time (MRT), as well as the morphology of the nanoparticles, the drug-excipient compatibility, and the release kinetics along with the drug diffusion mechanism were evaluated. The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide. The particle and release characteristics can be efficiently optimized using the Box-Behnken design. Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

No MeSH data available.


Interactive effect of a; the sodium alginate and chitosan concentrations on the particle size, b:and zeta potential absolute values, c; interactive effect of chitosan concentration and stirring speed on the mean release time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4317998&req=5

Figure 3: Interactive effect of a; the sodium alginate and chitosan concentrations on the particle size, b:and zeta potential absolute values, c; interactive effect of chitosan concentration and stirring speed on the mean release time.

Mentions: Fig. 3 includes 3D graphs depicting the interactive effect of alginate and chitosan concentrations, which proved to exert the most crucial impact upon two of the four responses, i.e. PS (Fig. 3a), and ZP (Fig. 3b), as well as the interactive effect of chitosan concentration and stirring speed upon MRT values (Fig. 3c). The graphs will be discussed in more detail in due course.


Preparation, characterization and optimization of glipizide controlled release nanoparticles.

Emami J, Boushehri MS, Varshosaz J - Res Pharm Sci (2014 Sep-Oct)

Interactive effect of a; the sodium alginate and chitosan concentrations on the particle size, b:and zeta potential absolute values, c; interactive effect of chitosan concentration and stirring speed on the mean release time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317998&req=5

Figure 3: Interactive effect of a; the sodium alginate and chitosan concentrations on the particle size, b:and zeta potential absolute values, c; interactive effect of chitosan concentration and stirring speed on the mean release time.
Mentions: Fig. 3 includes 3D graphs depicting the interactive effect of alginate and chitosan concentrations, which proved to exert the most crucial impact upon two of the four responses, i.e. PS (Fig. 3a), and ZP (Fig. 3b), as well as the interactive effect of chitosan concentration and stirring speed upon MRT values (Fig. 3c). The graphs will be discussed in more detail in due course.

Bottom Line: The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide.The particle and release characteristics can be efficiently optimized using the Box-Behnken design.Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, I.R. Iran.

ABSTRACT
The purpose of the present study was to develop glipizide controlled release nanoparticles using alginate and chitosan thorough ionotropic controlled gelation method. Glipizide is a frequently prescribed second generation sulfonylurea which lowers the blood glucose in type-two diabetics. Quick absorption of the drug from the gastrointestinal tract along with short half- life of elimination makes it a good candidate for controlled release formulations. Alginate-chitosan nanoparticles (ACNP) are convenient controlled delivery systems for glipizide, due to both the release limiting properties of the system, and the bioadhesive nature of the polymers. In the present study, glipizide loaded alginate-chitosan nanoparticles (GlACNP) were prepared, and the particle characteristics including particle size (PS), zeta potential (ZP), entrapment efficiency (EE%), loading percent (LP), and mean release time (MRT), as well as the morphology of the nanoparticles, the drug-excipient compatibility, and the release kinetics along with the drug diffusion mechanism were evaluated. The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide. The particle and release characteristics can be efficiently optimized using the Box-Behnken design. Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

No MeSH data available.