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Preparation, characterization and optimization of glipizide controlled release nanoparticles.

Emami J, Boushehri MS, Varshosaz J - Res Pharm Sci (2014 Sep-Oct)

Bottom Line: The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide.The particle and release characteristics can be efficiently optimized using the Box-Behnken design.Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, I.R. Iran.

ABSTRACT
The purpose of the present study was to develop glipizide controlled release nanoparticles using alginate and chitosan thorough ionotropic controlled gelation method. Glipizide is a frequently prescribed second generation sulfonylurea which lowers the blood glucose in type-two diabetics. Quick absorption of the drug from the gastrointestinal tract along with short half- life of elimination makes it a good candidate for controlled release formulations. Alginate-chitosan nanoparticles (ACNP) are convenient controlled delivery systems for glipizide, due to both the release limiting properties of the system, and the bioadhesive nature of the polymers. In the present study, glipizide loaded alginate-chitosan nanoparticles (GlACNP) were prepared, and the particle characteristics including particle size (PS), zeta potential (ZP), entrapment efficiency (EE%), loading percent (LP), and mean release time (MRT), as well as the morphology of the nanoparticles, the drug-excipient compatibility, and the release kinetics along with the drug diffusion mechanism were evaluated. The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide. The particle and release characteristics can be efficiently optimized using the Box-Behnken design. Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

No MeSH data available.


Size and morphology of the optimized formulation.
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Figure 1: Size and morphology of the optimized formulation.

Mentions: Based on the 27 different formulations designed by the Design Expert® software, particles with a wide average size range from 173 nm to 4522 nm were obtained (Table 2). Amongst these, particles smaller than 1000 nm are believed to better fit the oral administration (18). Due to the better particle size dispersion, however, a particle size range of 150-650 nm was selected for the optimization purposes. The size and morphology of the optimized formulation evaluated using SEM is shown in Fig. 1.


Preparation, characterization and optimization of glipizide controlled release nanoparticles.

Emami J, Boushehri MS, Varshosaz J - Res Pharm Sci (2014 Sep-Oct)

Size and morphology of the optimized formulation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317998&req=5

Figure 1: Size and morphology of the optimized formulation.
Mentions: Based on the 27 different formulations designed by the Design Expert® software, particles with a wide average size range from 173 nm to 4522 nm were obtained (Table 2). Amongst these, particles smaller than 1000 nm are believed to better fit the oral administration (18). Due to the better particle size dispersion, however, a particle size range of 150-650 nm was selected for the optimization purposes. The size and morphology of the optimized formulation evaluated using SEM is shown in Fig. 1.

Bottom Line: The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide.The particle and release characteristics can be efficiently optimized using the Box-Behnken design.Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, I.R. Iran.

ABSTRACT
The purpose of the present study was to develop glipizide controlled release nanoparticles using alginate and chitosan thorough ionotropic controlled gelation method. Glipizide is a frequently prescribed second generation sulfonylurea which lowers the blood glucose in type-two diabetics. Quick absorption of the drug from the gastrointestinal tract along with short half- life of elimination makes it a good candidate for controlled release formulations. Alginate-chitosan nanoparticles (ACNP) are convenient controlled delivery systems for glipizide, due to both the release limiting properties of the system, and the bioadhesive nature of the polymers. In the present study, glipizide loaded alginate-chitosan nanoparticles (GlACNP) were prepared, and the particle characteristics including particle size (PS), zeta potential (ZP), entrapment efficiency (EE%), loading percent (LP), and mean release time (MRT), as well as the morphology of the nanoparticles, the drug-excipient compatibility, and the release kinetics along with the drug diffusion mechanism were evaluated. The results suggested that ionotropic controlled gelation method offers the possibility of preparing the nanoparticles in mild conditions in an aqueous environment, and can lead to the preparation of particles with favorable size, controlled release characteristics, and high entrapment efficiency, serving as a convenient delivery system for glipizide. The particle and release characteristics can be efficiently optimized using the Box-Behnken design. Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available glipizide delivery systems.

No MeSH data available.