Impact of alcohol consumption on survival in patients with esophageal carcinoma: a large cohort with long-term follow-up.
Bottom Line: The median overall survival (OS; 42 months) and disease-free survival (DFS; 33 months) for never-drinkers were significantly higher than ever-drinkers (27 and 22 months, respectively).The hazardous effect on OS and DFS of drinking grew statistically significantly in a dose-dependent manner with increasing amount of alcohol consumption per day (both P-value for trend < 0.05).The predictive effect of drinking on OS (P = 0.596) or DFS (P = 0.207) was not significant in the subgroup with esophageal adenocarcinoma (n = 195).
Affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Guangdong Esophageal Cancer Institute, Guangzhou, China.Show MeSH
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Mentions: The median follow-up was 64 months with a follow-up rate of 83.9%, and the median OS and DFS was 36 months (95% CI, 32.6–39.4) and 29 months (95% CI, 25.7–32.3). The median OS for never-drinkers and ever-drinkers was 42 months (95% CI, 35.7–48.2) and 27 months (95% CI, 22.8–31.2), and median DFS was 33 months (95% CI, 28.5–37.5) and 22 months (95% CI, 18.5–25.5), respectively. The crude Kaplan–Meier survival curves in Figure 1(a,b) showed worse prognosis among ever-drinkers in terms of OS and DFS (both log–rank P < 0.001), and the univariate HR for ever-drinkers was 1.43 (95% CI, 1.27–1.61; P < 0.001) and 1.34 (95% CI, 1.21–1.53; P < 0.001) for OS and DFS, respectively.
Affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Guangdong Esophageal Cancer Institute, Guangzhou, China.