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Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer.

Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Horiguchi H, Hiraki S, Ono S, Miyazaki H, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K - Cancer Sci. (2014)

Bottom Line: Although there have been multiple advances in the development of novel anticancer agents and operative procedures, prognosis of patients with advanced gastric cancer remains poor, especially in patients with peritoneal metastasis.Forty-eight hours after injection of the photosensitizer, in vivo and ex vivo imaging was carried out.In conclusion, ICGm can be used as a novel diagnostic and therapeutic nanodevice in peritoneal dissemination of gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Defense Medical College, Tokorozawa, Japan.

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Total weight and number of disseminated nodules in mice treated with indocyanine green (ICG) or ICG loaded lactosome (ICGm). *P < 0.05 versus ICG-treated mice.
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fig05: Total weight and number of disseminated nodules in mice treated with indocyanine green (ICG) or ICG loaded lactosome (ICGm). *P < 0.05 versus ICG-treated mice.

Mentions: Although the overall body weight of ICG-treated mice gradually decreased throughout the investigation period, this weight loss was not observed in ICGm-treated mice (Fig. 4). The weight of the total disseminated nodules in ICGm-treated mice was significantly lower than that of ICG-treated mice, and there were fewer disseminated nodules in ICGm-treated mice than in ICG-treated mice (Fig. 5). Photodynamic therapy using ICGm significantly improved survival rate compared to that using ICG (log–rank, P < 0.05); the median survival time of ICGm-treated mice after PDT was 32 days (n = 8) and that of ICG-treated mice was 17 days after PDT (n = 8) (Fig. 6).


Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer.

Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Horiguchi H, Hiraki S, Ono S, Miyazaki H, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K - Cancer Sci. (2014)

Total weight and number of disseminated nodules in mice treated with indocyanine green (ICG) or ICG loaded lactosome (ICGm). *P < 0.05 versus ICG-treated mice.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317961&req=5

fig05: Total weight and number of disseminated nodules in mice treated with indocyanine green (ICG) or ICG loaded lactosome (ICGm). *P < 0.05 versus ICG-treated mice.
Mentions: Although the overall body weight of ICG-treated mice gradually decreased throughout the investigation period, this weight loss was not observed in ICGm-treated mice (Fig. 4). The weight of the total disseminated nodules in ICGm-treated mice was significantly lower than that of ICG-treated mice, and there were fewer disseminated nodules in ICGm-treated mice than in ICG-treated mice (Fig. 5). Photodynamic therapy using ICGm significantly improved survival rate compared to that using ICG (log–rank, P < 0.05); the median survival time of ICGm-treated mice after PDT was 32 days (n = 8) and that of ICG-treated mice was 17 days after PDT (n = 8) (Fig. 6).

Bottom Line: Although there have been multiple advances in the development of novel anticancer agents and operative procedures, prognosis of patients with advanced gastric cancer remains poor, especially in patients with peritoneal metastasis.Forty-eight hours after injection of the photosensitizer, in vivo and ex vivo imaging was carried out.In conclusion, ICGm can be used as a novel diagnostic and therapeutic nanodevice in peritoneal dissemination of gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Defense Medical College, Tokorozawa, Japan.

Show MeSH
Related in: MedlinePlus