Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer.
Bottom Line: Forty-eight hours after injection of the photosensitizer, in vivo and ex vivo imaging was carried out.The PDT reduced the total weight of the disseminated nodules and significantly improved weight loss and survival rate in ICGm-treated mice.In conclusion, ICGm can be used as a novel diagnostic and therapeutic nanodevice in peritoneal dissemination of gastric cancer.
Affiliation: Department of Surgery, National Defense Medical College, Tokorozawa, Japan.Show MeSH
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Mentions: We detected luminescent signals through the abdominal wall as well as in the post-laparotomy abdominal cavity in both treatment groups (Fig. 2). Fluorescence imaging revealed that no specific fluorescence was observed in ICG-treated mice through the abdominal wall or post-laparotomy abdominal cavity (Fig. 2a), whereas we detected fluorescence in the location identical to the site of luminescence in ICGm-treated mice (Fig. 2b). Although we detected luminescent signals in disseminated nodules in both groups, disseminated nodules in ICGm-treated mice, but not ICG-treated mice, were visualized in ex vivo fluorescence imaging (Fig. 3).
Affiliation: Department of Surgery, National Defense Medical College, Tokorozawa, Japan.