Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer.
Bottom Line: Briefly, As2 O3 inhibited the activations/expressions of both TGFβ-induced and endogenous SMAD2/3.Furthermore, As2 O3 improved the expression of miR-155 via DNA-demethylation.MiR-155, which targeted the SMAD2-3'UTR, decreased the expression and function of SMAD2.
Affiliation: Affiliated Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China.Show MeSH
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Mentions: Collectively, in human prostate cancer cells, As2O3 blocked angiogenesis through the inhibition of TGF-β/SMAD signal pathway in vitro and in vivo. Indeed, As2O3 improved the expression of miR-155 via DNA-demethylation. As an upstream regulator of TGF-β signaling, miR-155 decreased the expression and function of SMAD2 by targeting the SMAD2-3′UTR. Knockdown of miR-155 abolished the As2O3-induced inhibitions of TGF-β/SMAD2 signaling, VEGF secretion and angiogenesis (Fig. 7).
Affiliation: Affiliated Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China.