Anemia as a useful biomarker in patients with diffuse large B-cell lymphoma treated with R-CHOP immunochemotherapy.
Bottom Line: This finding was observed irrespective of the status of pre-treatment bone marrow involvement.In multivariate analysis, hemoglobin <10 g/dL was found to be an international prognostic index-independent prognostic factor.Risk of relapse was significantly higher for patients who were still anemic at 6 months after R-CHOP, compared to those who achieved complete recovery from chemotherapy-induced anemia within 6 months.
Affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.Show MeSH
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Mentions: The mean baseline Hb was 11.9 ± SD 1.8 g/dL in male patients and 10.9 ± SD 1.6 g/dL in female patients (P = 0.001). One hundred and twenty-one patients (77.1%) had G ≥ 1 and 34 patients (21.7%) had G ≥ 2 baseline anemia. Patients with a CIA of G ≥ 2 anemia showed inferior EFS compared to those with no (G0) or G1 anemia (Fig. 1a,b). Among 10 patients who had TRM, 7 had G ≥ 2 baseline anemia (P = 0.001). However, such a significant difference of survival between patients with G ≥ 2 anemia and those with G0 or 1 anemia was well maintained in analysis of DFS instead of EFS (P < 0.001; Fig. 1c).
Affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.