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Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.

Ema A, Yamashita K, Ushiku H, Kojo K, Minatani N, Kikuchi M, Mieno H, Moriya H, Hosoda K, Katada N, Kikuchi S, Watanabe M - Cancer Sci. (2014)

Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

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The 5y-RFS of patients with 13th JGCA pathological stage IIIB tumors with the indicated RTK expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. The 5y-RFS of patients with HER3 and EphA2 overexpression was statistically significantly different from that of patients with no HER3 or EphA2 expression respectively (HER3; P = 0.019, EphA2; P = 0.042). EGFR, HER2 and IGF-1R overexpression also tended to indicate poor prognosis in 13th JGCA stage IIIB tumors.
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fig05: The 5y-RFS of patients with 13th JGCA pathological stage IIIB tumors with the indicated RTK expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. The 5y-RFS of patients with HER3 and EphA2 overexpression was statistically significantly different from that of patients with no HER3 or EphA2 expression respectively (HER3; P = 0.019, EphA2; P = 0.042). EGFR, HER2 and IGF-1R overexpression also tended to indicate poor prognosis in 13th JGCA stage IIIB tumors.

Mentions: We analyzed the prognostic significance of expression of each RTK in advanced gastric cancer, focusing on the 13th JGCA pathological stage IIIB of gastric cancer, using the log-rank test (Fig. 5). When HER3 expression of these tumors was classified into IHC 0 (n = 12) and IHC 1+/2+ (n = 24), the 5y-RFS was 75.0% and 28.6% respectively, and this difference was statistically significant (P = 0.019). EphA2 expression was also classified into IHC 0 (n = 17) and IHC 1+/2+ (n = 19), the 5y-RFS was 54.8% and 31.6% respectively. This difference was also statistically significant (P = 0.042).


Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.

Ema A, Yamashita K, Ushiku H, Kojo K, Minatani N, Kikuchi M, Mieno H, Moriya H, Hosoda K, Katada N, Kikuchi S, Watanabe M - Cancer Sci. (2014)

The 5y-RFS of patients with 13th JGCA pathological stage IIIB tumors with the indicated RTK expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. The 5y-RFS of patients with HER3 and EphA2 overexpression was statistically significantly different from that of patients with no HER3 or EphA2 expression respectively (HER3; P = 0.019, EphA2; P = 0.042). EGFR, HER2 and IGF-1R overexpression also tended to indicate poor prognosis in 13th JGCA stage IIIB tumors.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317956&req=5

fig05: The 5y-RFS of patients with 13th JGCA pathological stage IIIB tumors with the indicated RTK expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. The 5y-RFS of patients with HER3 and EphA2 overexpression was statistically significantly different from that of patients with no HER3 or EphA2 expression respectively (HER3; P = 0.019, EphA2; P = 0.042). EGFR, HER2 and IGF-1R overexpression also tended to indicate poor prognosis in 13th JGCA stage IIIB tumors.
Mentions: We analyzed the prognostic significance of expression of each RTK in advanced gastric cancer, focusing on the 13th JGCA pathological stage IIIB of gastric cancer, using the log-rank test (Fig. 5). When HER3 expression of these tumors was classified into IHC 0 (n = 12) and IHC 1+/2+ (n = 24), the 5y-RFS was 75.0% and 28.6% respectively, and this difference was statistically significant (P = 0.019). EphA2 expression was also classified into IHC 0 (n = 17) and IHC 1+/2+ (n = 19), the 5y-RFS was 54.8% and 31.6% respectively. This difference was also statistically significant (P = 0.042).

Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Show MeSH
Related in: MedlinePlus