Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.
Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.
Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.Show MeSH
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Mentions: We analyzed the prognostic significance of expression of each RTK in advanced gastric cancer, focusing on the 13th JGCA pathological stage IIIB of gastric cancer, using the log-rank test (Fig. 5). When HER3 expression of these tumors was classified into IHC 0 (n = 12) and IHC 1+/2+ (n = 24), the 5y-RFS was 75.0% and 28.6% respectively, and this difference was statistically significant (P = 0.019). EphA2 expression was also classified into IHC 0 (n = 17) and IHC 1+/2+ (n = 19), the 5y-RFS was 54.8% and 31.6% respectively. This difference was also statistically significant (P = 0.042).
Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.