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Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.

Ema A, Yamashita K, Ushiku H, Kojo K, Minatani N, Kikuchi M, Mieno H, Moriya H, Hosoda K, Katada N, Kikuchi S, Watanabe M - Cancer Sci. (2014)

Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

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The 5y-RFS of patients with different levels of HER3 expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. (a) HER3 expression of IHC 1+ and IHC 2+ displayed a poor prognosis compared with HER3 IHC 0. (b) HER3 overexpression (IHC 1+/2+) displayed poor prognosis (P = 0.0034).
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fig03: The 5y-RFS of patients with different levels of HER3 expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. (a) HER3 expression of IHC 1+ and IHC 2+ displayed a poor prognosis compared with HER3 IHC 0. (b) HER3 overexpression (IHC 1+/2+) displayed poor prognosis (P = 0.0034).

Mentions: Kaplan-Meier curves of the survival of patients with different levels of HER3 expression are shown in Fig. 3a. Significantly higher survival of patients with HER3 IHC 0 was found compared with patients with HER3 IHC 1+ (P = 0.0083), or HER3 IHC 2+ (P = 0.0059). The 5y-RFS was 82.9%, 58.0% and 52.3% respectively. When HER3 expression was classified into IHC 0 (n = 69; 41.3%) and IHC 1+/2+ (n = 98; 58.7%), the 5y-RFS was 82.9% and 56.5% respectively, and the difference was again statistically significant (P = 0.0034) (Fig. 3b). Thus, HER3 overexpression (IHC 1+/2+) exhibited poor prognosis.


Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.

Ema A, Yamashita K, Ushiku H, Kojo K, Minatani N, Kikuchi M, Mieno H, Moriya H, Hosoda K, Katada N, Kikuchi S, Watanabe M - Cancer Sci. (2014)

The 5y-RFS of patients with different levels of HER3 expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. (a) HER3 expression of IHC 1+ and IHC 2+ displayed a poor prognosis compared with HER3 IHC 0. (b) HER3 overexpression (IHC 1+/2+) displayed poor prognosis (P = 0.0034).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317956&req=5

fig03: The 5y-RFS of patients with different levels of HER3 expression, as detected using IHC, was analyzed using Kaplan Meier survival curves. (a) HER3 expression of IHC 1+ and IHC 2+ displayed a poor prognosis compared with HER3 IHC 0. (b) HER3 overexpression (IHC 1+/2+) displayed poor prognosis (P = 0.0034).
Mentions: Kaplan-Meier curves of the survival of patients with different levels of HER3 expression are shown in Fig. 3a. Significantly higher survival of patients with HER3 IHC 0 was found compared with patients with HER3 IHC 1+ (P = 0.0083), or HER3 IHC 2+ (P = 0.0059). The 5y-RFS was 82.9%, 58.0% and 52.3% respectively. When HER3 expression was classified into IHC 0 (n = 69; 41.3%) and IHC 1+/2+ (n = 98; 58.7%), the 5y-RFS was 82.9% and 56.5% respectively, and the difference was again statistically significant (P = 0.0034) (Fig. 3b). Thus, HER3 overexpression (IHC 1+/2+) exhibited poor prognosis.

Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Show MeSH
Related in: MedlinePlus