Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.
Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.
Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.Show MeSH
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Mentions: Kaplan-Meier curves of the survival of patients with different levels of HER3 expression are shown in Fig. 3a. Significantly higher survival of patients with HER3 IHC 0 was found compared with patients with HER3 IHC 1+ (P = 0.0083), or HER3 IHC 2+ (P = 0.0059). The 5y-RFS was 82.9%, 58.0% and 52.3% respectively. When HER3 expression was classified into IHC 0 (n = 69; 41.3%) and IHC 1+/2+ (n = 98; 58.7%), the 5y-RFS was 82.9% and 56.5% respectively, and the difference was again statistically significant (P = 0.0034) (Fig. 3b). Thus, HER3 overexpression (IHC 1+/2+) exhibited poor prognosis.
Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.