Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.
Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.
Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.Show MeSH
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Mentions: We also investigated the correlation of each RTK expression with the expression of other RTKs, as judged by immunohistochemical staining (Fig. 2a). Intriguingly, HER3 overexpression was closely correlated with overexpressed IGF-1R (P < 0.0001, R = 0.41) and EphA2 (P < 0.0001, R = 0.34) (Table 1 and Fig. 2a). On the other hand, HER3 overexpression showed no correlation with EGFR and HER2 overexpression.
Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.