Limits...
Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.

Ema A, Yamashita K, Ushiku H, Kojo K, Minatani N, Kikuchi M, Mieno H, Moriya H, Hosoda K, Katada N, Kikuchi S, Watanabe M - Cancer Sci. (2014)

Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Show MeSH

Related in: MedlinePlus

Correlation of the immunostained expression of each RTK with other RTKs, and RTK expression pattern of recurrent tumors. (a) Individual RTKs were immunohistochemically stained and their staining level in the same tumor was correlated with that of the other RTKs. HER3 expression was closely correlated with that of IGF-1R (P < 0.0001, R = 0.41), and EphA2 (P < 0.0001, R = 0.34). (b) The tumors of the 53 patients who recurred were immunohistochemically analyzed for RTK expression; 40 patients (75.5%) were HER3-positive, 39 patients (73.6%) were EGFR-positive, two patients (3.8%) were HER2-positive, 36 patients (67.9%) were IGF-1R-positive, and 27 patients (50.9%) were EphA2-receptor positive. Of the RTKs expressed, HER3 overexpression showed the highest association with recurrence.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4317956&req=5

fig02: Correlation of the immunostained expression of each RTK with other RTKs, and RTK expression pattern of recurrent tumors. (a) Individual RTKs were immunohistochemically stained and their staining level in the same tumor was correlated with that of the other RTKs. HER3 expression was closely correlated with that of IGF-1R (P < 0.0001, R = 0.41), and EphA2 (P < 0.0001, R = 0.34). (b) The tumors of the 53 patients who recurred were immunohistochemically analyzed for RTK expression; 40 patients (75.5%) were HER3-positive, 39 patients (73.6%) were EGFR-positive, two patients (3.8%) were HER2-positive, 36 patients (67.9%) were IGF-1R-positive, and 27 patients (50.9%) were EphA2-receptor positive. Of the RTKs expressed, HER3 overexpression showed the highest association with recurrence.

Mentions: We also investigated the correlation of each RTK expression with the expression of other RTKs, as judged by immunohistochemical staining (Fig. 2a). Intriguingly, HER3 overexpression was closely correlated with overexpressed IGF-1R (P < 0.0001, R = 0.41) and EphA2 (P < 0.0001, R = 0.34) (Table 1 and Fig. 2a). On the other hand, HER3 overexpression showed no correlation with EGFR and HER2 overexpression.


Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer.

Ema A, Yamashita K, Ushiku H, Kojo K, Minatani N, Kikuchi M, Mieno H, Moriya H, Hosoda K, Katada N, Kikuchi S, Watanabe M - Cancer Sci. (2014)

Correlation of the immunostained expression of each RTK with other RTKs, and RTK expression pattern of recurrent tumors. (a) Individual RTKs were immunohistochemically stained and their staining level in the same tumor was correlated with that of the other RTKs. HER3 expression was closely correlated with that of IGF-1R (P < 0.0001, R = 0.41), and EphA2 (P < 0.0001, R = 0.34). (b) The tumors of the 53 patients who recurred were immunohistochemically analyzed for RTK expression; 40 patients (75.5%) were HER3-positive, 39 patients (73.6%) were EGFR-positive, two patients (3.8%) were HER2-positive, 36 patients (67.9%) were IGF-1R-positive, and 27 patients (50.9%) were EphA2-receptor positive. Of the RTKs expressed, HER3 overexpression showed the highest association with recurrence.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317956&req=5

fig02: Correlation of the immunostained expression of each RTK with other RTKs, and RTK expression pattern of recurrent tumors. (a) Individual RTKs were immunohistochemically stained and their staining level in the same tumor was correlated with that of the other RTKs. HER3 expression was closely correlated with that of IGF-1R (P < 0.0001, R = 0.41), and EphA2 (P < 0.0001, R = 0.34). (b) The tumors of the 53 patients who recurred were immunohistochemically analyzed for RTK expression; 40 patients (75.5%) were HER3-positive, 39 patients (73.6%) were EGFR-positive, two patients (3.8%) were HER2-positive, 36 patients (67.9%) were IGF-1R-positive, and 27 patients (50.9%) were EphA2-receptor positive. Of the RTKs expressed, HER3 overexpression showed the highest association with recurrence.
Mentions: We also investigated the correlation of each RTK expression with the expression of other RTKs, as judged by immunohistochemical staining (Fig. 2a). Intriguingly, HER3 overexpression was closely correlated with overexpressed IGF-1R (P < 0.0001, R = 0.41) and EphA2 (P < 0.0001, R = 0.34) (Table 1 and Fig. 2a). On the other hand, HER3 overexpression showed no correlation with EGFR and HER2 overexpression.

Bottom Line: Analysis using a multivariate proportional hazard model identified the most significant RTKs that represented independent prognostic relevance.Significant prognostic relevance was similarly confirmed for IGF-1R (P = 0.014), and EGFR (P = 0.030), but not for EphA2 or HER2 expression.Of the 53 patients who recurred, 40 patients (75.5%) were HER3-positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Show MeSH
Related in: MedlinePlus