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miR-185-3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro.

Li G, Wang Y, Liu Y, Su Z, Liu C, Ren S, Deng T, Huang D, Tian Y, Qiu Y - Cancer Sci. (2014)

Bottom Line: Luciferase reporter assays confirmed that miR-185-3p directly targeted the coding region of WNT2B.Furthermore, we found radioresistance decreased in WNT2B-silenced NPC cells.We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China.

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MiR-185-3p expression in nasopharyngeal carcinoma cells. Expression of miR-185-3p is the lowest in CNE-2 cells and highest in 5-8F cells.
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fig01: MiR-185-3p expression in nasopharyngeal carcinoma cells. Expression of miR-185-3p is the lowest in CNE-2 cells and highest in 5-8F cells.

Mentions: To investigate the expression of miR-185-3p in NPC, qRT-PCR was applied to detect its expression level in four NPC cells, including CNE-2, HNE-1, 5-8F and 6-10B (Fig. 1). The results showed CNE-2 had the lowest expression and 5-8F had the highest expression of miR-185-3p, which were then selected for subsequent experiments.


miR-185-3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro.

Li G, Wang Y, Liu Y, Su Z, Liu C, Ren S, Deng T, Huang D, Tian Y, Qiu Y - Cancer Sci. (2014)

MiR-185-3p expression in nasopharyngeal carcinoma cells. Expression of miR-185-3p is the lowest in CNE-2 cells and highest in 5-8F cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317952&req=5

fig01: MiR-185-3p expression in nasopharyngeal carcinoma cells. Expression of miR-185-3p is the lowest in CNE-2 cells and highest in 5-8F cells.
Mentions: To investigate the expression of miR-185-3p in NPC, qRT-PCR was applied to detect its expression level in four NPC cells, including CNE-2, HNE-1, 5-8F and 6-10B (Fig. 1). The results showed CNE-2 had the lowest expression and 5-8F had the highest expression of miR-185-3p, which were then selected for subsequent experiments.

Bottom Line: Luciferase reporter assays confirmed that miR-185-3p directly targeted the coding region of WNT2B.Furthermore, we found radioresistance decreased in WNT2B-silenced NPC cells.We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan, China.

Show MeSH
Related in: MedlinePlus