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The poor prognosis speaks to the aggressive and poorly understood nature of its growth and invasiveness... In this research study, Matsushita and colleagues investigated the role of a well-known cancer target, Hedgehog (Hh), and examined its downstream effects in vitro in gallbladder tumor cells compared to normal cells... The researchers established elevated levels of Hh in cancer cells, then went on to trace its pathway... They found that inhibition of Hh ligand deactivates Smoothened (a regulatory protein) through a series of players which then decreased the invasiveness and epithelial–mesenchymal transition of the cancer cells... This study identified a potential pathway to target to reduce the aggressiveness of, and perhaps even treat, this deadly disease. doi: 10.1111/cas.12354 When the intent is cure, the goal of surgery in cancer is to achieve a complete resection of all cancer cells... Sophisticated imaging techniques are being studied for their potential to help identify the presence of micrometastases as well as serve other important functions, such as confirming tissue perfusion... In this exciting work, Nakajima and colleagues offer a significant improvement in standard fluorescence imaging, known as fluorescence lifetime... The authors describe a method that could dramatically improve upon this cutting-edge imaging technique to achieve complete resection of cancer cells. doi: 10.1111/cas.12343 Brain gliomas carry a poor prognosis and, although they rank among the most common primary brain tumors, little is understood of what drives their aggressive behavior... The presence of miR-16 was inversely correlated with the degree of glial cell malignancy, suggesting that it acts as a tumor suppressor... By identifying a potential factor in the progression of glial cell tumors, this work supports the value of further studies into the potential targeting of miR-16 for therapeutic purposes. doi: 10.1111/cas.12351

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The poor prognosis speaks to the aggressive and poorly understood nature of its growth and invasiveness... In this research study, Matsushita and colleagues investigated the role of a well-known cancer target, Hedgehog (Hh), and examined its downstream effects in vitro in gallbladder tumor cells compared to normal cells... The researchers established elevated levels of Hh in cancer cells, then went on to trace its pathway... They found that inhibition of Hh ligand deactivates Smoothened (a regulatory protein) through a series of players which then decreased the invasiveness and epithelial–mesenchymal transition of the cancer cells... This study identified a potential pathway to target to reduce the aggressiveness of, and perhaps even treat, this deadly disease. doi: 10.1111/cas.12354 When the intent is cure, the goal of surgery in cancer is to achieve a complete resection of all cancer cells... Sophisticated imaging techniques are being studied for their potential to help identify the presence of micrometastases as well as serve other important functions, such as confirming tissue perfusion... In this exciting work, Nakajima and colleagues offer a significant improvement in standard fluorescence imaging, known as fluorescence lifetime... The authors describe a method that could dramatically improve upon this cutting-edge imaging technique to achieve complete resection of cancer cells. doi: 10.1111/cas.12343 Brain gliomas carry a poor prognosis and, although they rank among the most common primary brain tumors, little is understood of what drives their aggressive behavior... The presence of miR-16 was inversely correlated with the degree of glial cell malignancy, suggesting that it acts as a tumor suppressor... By identifying a potential factor in the progression of glial cell tumors, this work supports the value of further studies into the potential targeting of miR-16 for therapeutic purposes. doi: 10.1111/cas.12351

No MeSH data available.