Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer.
Bottom Line: New effective therapeutic strategies are greatly needed.In contrast, inhibiting the effector Smo decreased the anchor-dependent and anchor-independent proliferation.These results suggest that Hh signaling is elevated in GBC and may be involved in the acquisition of malignant phenotypes, and that Hh signaling may be a potential therapeutic target for GBC.
Affiliation: Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Show MeSH
Related in: MedlinePlus
Mentions: We hypothesized that Hh signaling may contribute to the malignancy of GBC. We examined the impact of Hh activation on proliferation and invasiveness. The addition of rhShh augmented the proliferation rate (Fig.3a) and invasiveness (Fig.3b) of GBd15 and TGBC2TKB cells. These results indicate that activation of Hh signaling further enhances the proliferative and invasive phenotypes of GBC cells.
Affiliation: Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.