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Endoscopic findings using narrow-band imaging to distinguish between basal cell hyperplasia and carcinoma of the pharynx.

Yagishita A, Fujii S, Yano T, Kaneko K - Cancer Sci. (2014)

Bottom Line: The clinicopathological factors were also compared.The size of the BCH lesions was significantly smaller (P < 0.001), and their intervascular transparency was more clearly observed (P < 0.001).Intra-epithelial papillary capillary loop (IPCL) shapes were less variable and monotonous (P < 0.001), and the distribution of the IPCL was more regular with an interval comparable to that of SCC (P < 0.001), although no significant differences in the sharpness of the lesion border, dilatation of IPCL and tortuosity of the IPCL were seen between the BCH and SCC lesions.

View Article: PubMed Central - PubMed

Affiliation: Endoscopy Division, Department of Gastroenterology, National Cancer Center Hospital East, Chiba, Japan.

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Narrow-band imaging (NBI) view and pathological findings of basal cell hyperplasia (BCH) and head and neck squamous cell carcinoma (HNSCC). (a) NBI view of BCH (arrowhead) without magnification. (b) NBI view of BCH with magnification. (c,d) (c) Pathological findings of BCH. Basal cell hyperplasia is visible within the area around the dilated IPCL, and the maturation of superficial cells is preserved. (d) The area around IPCL in figure (c) was enlarged. (e) NBI view of HNSCC with magnification. (f) Pathological findings of HNSCC, H.E. The whole epithelial layer is occupied by atypical cells.
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fig01: Narrow-band imaging (NBI) view and pathological findings of basal cell hyperplasia (BCH) and head and neck squamous cell carcinoma (HNSCC). (a) NBI view of BCH (arrowhead) without magnification. (b) NBI view of BCH with magnification. (c,d) (c) Pathological findings of BCH. Basal cell hyperplasia is visible within the area around the dilated IPCL, and the maturation of superficial cells is preserved. (d) The area around IPCL in figure (c) was enlarged. (e) NBI view of HNSCC with magnification. (f) Pathological findings of HNSCC, H.E. The whole epithelial layer is occupied by atypical cells.

Mentions: Typical BCH and HNSCC cases are shown in Fig. 1. Both lesions were recognized as brownish areas on the NBI images; however, intervascular transparency and a regular distribution were only observed in the BCH lesion. The endoscopic findings for the BCH and SCC lesions are shown in Table 3. The typical findings for BCH were defined as a regular distribution of IPCL composed of 2–4 loop-shaped (“lasso-like”) capillaries, with all the cases except for one exhibiting this typical finding (Fig. 1). As a result, the BCH were significantly smaller (P < 0.001), had a more preserved intervascular transparency (flat type) (P < 0.001), had fewer variations in IPCL shapes (P < 0.001) and had a more regular distribution of IPCL (P < 0.001) than the SCC. In contrast, no significant difference in the sharpness of the margin was seen between the BCH and SCC lesions (P = 0.17), and the IPCL of both of them were dilated and tortuous. Among the 21 cases of non-elevated (flat or mixed with flat and elevated) BCH, the intervascular transparency was not impaired in any of the cases (i.e. preserved or slightly impaired) and the intervascular color changes were positive in two cases (10%, 2/21). Among the 26 cases of non-elevated (flat or depressed) SCC, 20 cases (77%) had an impaired intervascular transparency, and among the remaining 6 cases, the intervascular color change was positive in 3 cases (50%, 3/6). The features of BCH and SCC are summarized in Fig. 2.


Endoscopic findings using narrow-band imaging to distinguish between basal cell hyperplasia and carcinoma of the pharynx.

Yagishita A, Fujii S, Yano T, Kaneko K - Cancer Sci. (2014)

Narrow-band imaging (NBI) view and pathological findings of basal cell hyperplasia (BCH) and head and neck squamous cell carcinoma (HNSCC). (a) NBI view of BCH (arrowhead) without magnification. (b) NBI view of BCH with magnification. (c,d) (c) Pathological findings of BCH. Basal cell hyperplasia is visible within the area around the dilated IPCL, and the maturation of superficial cells is preserved. (d) The area around IPCL in figure (c) was enlarged. (e) NBI view of HNSCC with magnification. (f) Pathological findings of HNSCC, H.E. The whole epithelial layer is occupied by atypical cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317933&req=5

fig01: Narrow-band imaging (NBI) view and pathological findings of basal cell hyperplasia (BCH) and head and neck squamous cell carcinoma (HNSCC). (a) NBI view of BCH (arrowhead) without magnification. (b) NBI view of BCH with magnification. (c,d) (c) Pathological findings of BCH. Basal cell hyperplasia is visible within the area around the dilated IPCL, and the maturation of superficial cells is preserved. (d) The area around IPCL in figure (c) was enlarged. (e) NBI view of HNSCC with magnification. (f) Pathological findings of HNSCC, H.E. The whole epithelial layer is occupied by atypical cells.
Mentions: Typical BCH and HNSCC cases are shown in Fig. 1. Both lesions were recognized as brownish areas on the NBI images; however, intervascular transparency and a regular distribution were only observed in the BCH lesion. The endoscopic findings for the BCH and SCC lesions are shown in Table 3. The typical findings for BCH were defined as a regular distribution of IPCL composed of 2–4 loop-shaped (“lasso-like”) capillaries, with all the cases except for one exhibiting this typical finding (Fig. 1). As a result, the BCH were significantly smaller (P < 0.001), had a more preserved intervascular transparency (flat type) (P < 0.001), had fewer variations in IPCL shapes (P < 0.001) and had a more regular distribution of IPCL (P < 0.001) than the SCC. In contrast, no significant difference in the sharpness of the margin was seen between the BCH and SCC lesions (P = 0.17), and the IPCL of both of them were dilated and tortuous. Among the 21 cases of non-elevated (flat or mixed with flat and elevated) BCH, the intervascular transparency was not impaired in any of the cases (i.e. preserved or slightly impaired) and the intervascular color changes were positive in two cases (10%, 2/21). Among the 26 cases of non-elevated (flat or depressed) SCC, 20 cases (77%) had an impaired intervascular transparency, and among the remaining 6 cases, the intervascular color change was positive in 3 cases (50%, 3/6). The features of BCH and SCC are summarized in Fig. 2.

Bottom Line: The clinicopathological factors were also compared.The size of the BCH lesions was significantly smaller (P < 0.001), and their intervascular transparency was more clearly observed (P < 0.001).Intra-epithelial papillary capillary loop (IPCL) shapes were less variable and monotonous (P < 0.001), and the distribution of the IPCL was more regular with an interval comparable to that of SCC (P < 0.001), although no significant differences in the sharpness of the lesion border, dilatation of IPCL and tortuosity of the IPCL were seen between the BCH and SCC lesions.

View Article: PubMed Central - PubMed

Affiliation: Endoscopy Division, Department of Gastroenterology, National Cancer Center Hospital East, Chiba, Japan.

Show MeSH
Related in: MedlinePlus