Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer.
Bottom Line: Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa.Luciferase reporter assays showed that miR-218 directly regulated expression of LASP1.Our data on pathways regulated by tumor-suppressive miR-218 provide new insight into the potential mechanisms of PCa oncogenesis and metastasis.
Affiliation: Department of Functional Genomics, Chiba, Japan; Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.Show MeSH
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Mentions: We determined the expression levels of LASP1 in PCa specimens by immunohistochemical staining. LASP1 was strongly expressed in several cancer lesions, whereas no or low expression was observed in normal regions (Fig. 6). There was no significant correlation between LASP1 expression and various tested clinicopathological parameters (Gleason score and stages, data not shown).
Affiliation: Department of Functional Genomics, Chiba, Japan; Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.