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Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer.

Nishikawa R, Goto Y, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, Kinoshita T, Yamamoto N, Nakagawa M, Naya Y, Ichikawa T, Seki N - Cancer Sci. (2014)

Bottom Line: Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa.LASP1 is a cytoskeletal scaffold protein that plays critical roles in cytoskeletal organization and cell migration.Our data on pathways regulated by tumor-suppressive miR-218 provide new insight into the potential mechanisms of PCa oncogenesis and metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Functional Genomics, Chiba, Japan; Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.

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Immunohistochemical staining of LASP1 in prostate clinical specimens. Differences in LASP1 expression were observed in cancer lesions and adjacent normal prostate tissues in the same fields: (a) patient number 6; and (b) patient number 16. Overexpression of LASP1 was observed in cancer lesions. In contrast, negative staining of LASP1 in normal prostate glands and stromal tissues (left panel, original magnification ×50; right panel, original magnification ×100).
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fig06: Immunohistochemical staining of LASP1 in prostate clinical specimens. Differences in LASP1 expression were observed in cancer lesions and adjacent normal prostate tissues in the same fields: (a) patient number 6; and (b) patient number 16. Overexpression of LASP1 was observed in cancer lesions. In contrast, negative staining of LASP1 in normal prostate glands and stromal tissues (left panel, original magnification ×50; right panel, original magnification ×100).

Mentions: We determined the expression levels of LASP1 in PCa specimens by immunohistochemical staining. LASP1 was strongly expressed in several cancer lesions, whereas no or low expression was observed in normal regions (Fig. 6). There was no significant correlation between LASP1 expression and various tested clinicopathological parameters (Gleason score and stages, data not shown).


Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer.

Nishikawa R, Goto Y, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, Kinoshita T, Yamamoto N, Nakagawa M, Naya Y, Ichikawa T, Seki N - Cancer Sci. (2014)

Immunohistochemical staining of LASP1 in prostate clinical specimens. Differences in LASP1 expression were observed in cancer lesions and adjacent normal prostate tissues in the same fields: (a) patient number 6; and (b) patient number 16. Overexpression of LASP1 was observed in cancer lesions. In contrast, negative staining of LASP1 in normal prostate glands and stromal tissues (left panel, original magnification ×50; right panel, original magnification ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317931&req=5

fig06: Immunohistochemical staining of LASP1 in prostate clinical specimens. Differences in LASP1 expression were observed in cancer lesions and adjacent normal prostate tissues in the same fields: (a) patient number 6; and (b) patient number 16. Overexpression of LASP1 was observed in cancer lesions. In contrast, negative staining of LASP1 in normal prostate glands and stromal tissues (left panel, original magnification ×50; right panel, original magnification ×100).
Mentions: We determined the expression levels of LASP1 in PCa specimens by immunohistochemical staining. LASP1 was strongly expressed in several cancer lesions, whereas no or low expression was observed in normal regions (Fig. 6). There was no significant correlation between LASP1 expression and various tested clinicopathological parameters (Gleason score and stages, data not shown).

Bottom Line: Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa.LASP1 is a cytoskeletal scaffold protein that plays critical roles in cytoskeletal organization and cell migration.Our data on pathways regulated by tumor-suppressive miR-218 provide new insight into the potential mechanisms of PCa oncogenesis and metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Functional Genomics, Chiba, Japan; Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.

Show MeSH
Related in: MedlinePlus