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Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T - Cancer Sci. (2014)

Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.

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(a) Relation of histological findings and degree of relative hemoglobin (rtHb). A significantly higher mean rtHb value is observed in mucinous carcinoma (Muc; 2.8 ± 0.8 SD) than in normal breast rtHb (N; 1.1 ± 0.1 SD, P = 0.001). Mean rtHb was not significantly different between normal breasts and other histological types, ductal carcinoma in situ (DCIS; 1.4 ± 0.6 SD, P = 0.3) and invasive ductal carcinoma (IDC; 1.7 ± 1.1 SD, P = 0.2). Invasive lobular carcinoma (ILC) had relatively higher rtHb (2.1) whereas lobular carcinoma in situ (LCIS) had low rtHb (1.1) compared to a normal breast. Angiosarcoma (Angio) showed remarkably high rtHb (19.1). (b) Relationship of histological findings and degree of tumor tissue oxygen saturation (stO2). There were no significant differences in mean stO2 values between normal breast (N; 70.8 ± 1.7% SD) and other histological types, DCIS (66.2 ± 6.6% SD, P = 0.1), IDC (69.5 ± 4.5% SD, P = 0.5), and mucinous carcinoma (Muc; 61.8 ± 8.8% SD, P = 0.06).
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fig03: (a) Relation of histological findings and degree of relative hemoglobin (rtHb). A significantly higher mean rtHb value is observed in mucinous carcinoma (Muc; 2.8 ± 0.8 SD) than in normal breast rtHb (N; 1.1 ± 0.1 SD, P = 0.001). Mean rtHb was not significantly different between normal breasts and other histological types, ductal carcinoma in situ (DCIS; 1.4 ± 0.6 SD, P = 0.3) and invasive ductal carcinoma (IDC; 1.7 ± 1.1 SD, P = 0.2). Invasive lobular carcinoma (ILC) had relatively higher rtHb (2.1) whereas lobular carcinoma in situ (LCIS) had low rtHb (1.1) compared to a normal breast. Angiosarcoma (Angio) showed remarkably high rtHb (19.1). (b) Relationship of histological findings and degree of tumor tissue oxygen saturation (stO2). There were no significant differences in mean stO2 values between normal breast (N; 70.8 ± 1.7% SD) and other histological types, DCIS (66.2 ± 6.6% SD, P = 0.1), IDC (69.5 ± 4.5% SD, P = 0.5), and mucinous carcinoma (Muc; 61.8 ± 8.8% SD, P = 0.06).

Mentions: Figure 3(a) shows rtHb levels. In normal breast tissue, mean rtHb was 1.09 ± 0.1 SD. Compared with normal breast tissue, only mucinous carcinoma showed a significantly higher rtHb level, but there were no significant differences between normal breasts and other histological types. Figure 3(b) shows the mean stO2 of a normal breast (70.8% ± 1.7% SD) and a wide range of stO2 of malignant tumors (69% ± 5.3% SD).


Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T - Cancer Sci. (2014)

(a) Relation of histological findings and degree of relative hemoglobin (rtHb). A significantly higher mean rtHb value is observed in mucinous carcinoma (Muc; 2.8 ± 0.8 SD) than in normal breast rtHb (N; 1.1 ± 0.1 SD, P = 0.001). Mean rtHb was not significantly different between normal breasts and other histological types, ductal carcinoma in situ (DCIS; 1.4 ± 0.6 SD, P = 0.3) and invasive ductal carcinoma (IDC; 1.7 ± 1.1 SD, P = 0.2). Invasive lobular carcinoma (ILC) had relatively higher rtHb (2.1) whereas lobular carcinoma in situ (LCIS) had low rtHb (1.1) compared to a normal breast. Angiosarcoma (Angio) showed remarkably high rtHb (19.1). (b) Relationship of histological findings and degree of tumor tissue oxygen saturation (stO2). There were no significant differences in mean stO2 values between normal breast (N; 70.8 ± 1.7% SD) and other histological types, DCIS (66.2 ± 6.6% SD, P = 0.1), IDC (69.5 ± 4.5% SD, P = 0.5), and mucinous carcinoma (Muc; 61.8 ± 8.8% SD, P = 0.06).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317930&req=5

fig03: (a) Relation of histological findings and degree of relative hemoglobin (rtHb). A significantly higher mean rtHb value is observed in mucinous carcinoma (Muc; 2.8 ± 0.8 SD) than in normal breast rtHb (N; 1.1 ± 0.1 SD, P = 0.001). Mean rtHb was not significantly different between normal breasts and other histological types, ductal carcinoma in situ (DCIS; 1.4 ± 0.6 SD, P = 0.3) and invasive ductal carcinoma (IDC; 1.7 ± 1.1 SD, P = 0.2). Invasive lobular carcinoma (ILC) had relatively higher rtHb (2.1) whereas lobular carcinoma in situ (LCIS) had low rtHb (1.1) compared to a normal breast. Angiosarcoma (Angio) showed remarkably high rtHb (19.1). (b) Relationship of histological findings and degree of tumor tissue oxygen saturation (stO2). There were no significant differences in mean stO2 values between normal breast (N; 70.8 ± 1.7% SD) and other histological types, DCIS (66.2 ± 6.6% SD, P = 0.1), IDC (69.5 ± 4.5% SD, P = 0.5), and mucinous carcinoma (Muc; 61.8 ± 8.8% SD, P = 0.06).
Mentions: Figure 3(a) shows rtHb levels. In normal breast tissue, mean rtHb was 1.09 ± 0.1 SD. Compared with normal breast tissue, only mucinous carcinoma showed a significantly higher rtHb level, but there were no significant differences between normal breasts and other histological types. Figure 3(b) shows the mean stO2 of a normal breast (70.8% ± 1.7% SD) and a wide range of stO2 of malignant tumors (69% ± 5.3% SD).

Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.

Show MeSH
Related in: MedlinePlus