Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.
Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.
Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.Show MeSH
Related in: MedlinePlus
Mentions: Figure 3(a) shows rtHb levels. In normal breast tissue, mean rtHb was 1.09 ± 0.1 SD. Compared with normal breast tissue, only mucinous carcinoma showed a significantly higher rtHb level, but there were no significant differences between normal breasts and other histological types. Figure 3(b) shows the mean stO2 of a normal breast (70.8% ± 1.7% SD) and a wide range of stO2 of malignant tumors (69% ± 5.3% SD).
Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.