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Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T - Cancer Sci. (2014)

Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.

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Related in: MedlinePlus

Distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) in tumors and normal breasts. The scattergram shows distribution of absolute values of stO2 (%) versus tHb (μM) and in tumors (blank circle) and contralateral normal breast (cross). For the contralateral normal breast, we selected a grid map in a corresponding mirror image location.
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fig02: Distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) in tumors and normal breasts. The scattergram shows distribution of absolute values of stO2 (%) versus tHb (μM) and in tumors (blank circle) and contralateral normal breast (cross). For the contralateral normal breast, we selected a grid map in a corresponding mirror image location.

Mentions: Figure 2 shows a scattergraph of stO2 versus tHb. Malignant tumors showed significantly higher tHb and higher stO2 than did a contralateral normal breast.


Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T - Cancer Sci. (2014)

Distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) in tumors and normal breasts. The scattergram shows distribution of absolute values of stO2 (%) versus tHb (μM) and in tumors (blank circle) and contralateral normal breast (cross). For the contralateral normal breast, we selected a grid map in a corresponding mirror image location.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317930&req=5

fig02: Distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) in tumors and normal breasts. The scattergram shows distribution of absolute values of stO2 (%) versus tHb (μM) and in tumors (blank circle) and contralateral normal breast (cross). For the contralateral normal breast, we selected a grid map in a corresponding mirror image location.
Mentions: Figure 2 shows a scattergraph of stO2 versus tHb. Malignant tumors showed significantly higher tHb and higher stO2 than did a contralateral normal breast.

Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.

Show MeSH
Related in: MedlinePlus