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Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T - Cancer Sci. (2014)

Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.

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Related in: MedlinePlus

Hemoglobin map construction using the optical breast imaging system. Representative images include a palpable 38-mm mucinous carcinoma on the left breast in a 56-year-old woman. (a) Optical measurements comprising a grid map over tumor (7 × 7 points, 1-cm pitch) and normal breast tissue (5 × 5 points, 1-cm pitch) are taken using a handheld probe. (b) Ultrasound (US)-guided breast imaging system with time-resolved diffuse optical spectroscopy (DOS). (c) The images present distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) concentrations on both breasts. (d) A mediolateral oblique mammogram shows a round circumscribed mass (arrowhead) in the subareolar area. (e) A sagittal US image obtained at the 4 o'clock position in the left breast shows a lobulated hypoechoic shadowing mass (arrowhead). (f) Dynamic contrast-enhanced (DCE) MRI shows a solitary intensely enhancing mass (arrowhead) in the lower outer quadrant of the left breast. L, left; R, right.
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fig01: Hemoglobin map construction using the optical breast imaging system. Representative images include a palpable 38-mm mucinous carcinoma on the left breast in a 56-year-old woman. (a) Optical measurements comprising a grid map over tumor (7 × 7 points, 1-cm pitch) and normal breast tissue (5 × 5 points, 1-cm pitch) are taken using a handheld probe. (b) Ultrasound (US)-guided breast imaging system with time-resolved diffuse optical spectroscopy (DOS). (c) The images present distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) concentrations on both breasts. (d) A mediolateral oblique mammogram shows a round circumscribed mass (arrowhead) in the subareolar area. (e) A sagittal US image obtained at the 4 o'clock position in the left breast shows a lobulated hypoechoic shadowing mass (arrowhead). (f) Dynamic contrast-enhanced (DCE) MRI shows a solitary intensely enhancing mass (arrowhead) in the lower outer quadrant of the left breast. L, left; R, right.

Mentions: A region of interest (ROI)—a circle measuring 2 cm in radius—was assigned to the skin including the area of the lesion. The number of points included in an ROI was 10–14. We set the ROI showing the highest concentration of Hb. When we could not detect a hotspot, we set the ROI just above the lesion that was identified by US. We used the mean volume calculated from ROI analysis, automatically. The evaluation of Hb parameters was carried out as follows: tHb (μM) = O2Hb + HHb, stO2 (%) = O2Hb / tHb × 100, and rtHb = a ratio of tumor mean tHb to contralateral normal mean tHb. Figure 1 shows representative images of tHb and stO2 of both tumor-bearing and contralateral normal breast.


Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T - Cancer Sci. (2014)

Hemoglobin map construction using the optical breast imaging system. Representative images include a palpable 38-mm mucinous carcinoma on the left breast in a 56-year-old woman. (a) Optical measurements comprising a grid map over tumor (7 × 7 points, 1-cm pitch) and normal breast tissue (5 × 5 points, 1-cm pitch) are taken using a handheld probe. (b) Ultrasound (US)-guided breast imaging system with time-resolved diffuse optical spectroscopy (DOS). (c) The images present distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) concentrations on both breasts. (d) A mediolateral oblique mammogram shows a round circumscribed mass (arrowhead) in the subareolar area. (e) A sagittal US image obtained at the 4 o'clock position in the left breast shows a lobulated hypoechoic shadowing mass (arrowhead). (f) Dynamic contrast-enhanced (DCE) MRI shows a solitary intensely enhancing mass (arrowhead) in the lower outer quadrant of the left breast. L, left; R, right.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317930&req=5

fig01: Hemoglobin map construction using the optical breast imaging system. Representative images include a palpable 38-mm mucinous carcinoma on the left breast in a 56-year-old woman. (a) Optical measurements comprising a grid map over tumor (7 × 7 points, 1-cm pitch) and normal breast tissue (5 × 5 points, 1-cm pitch) are taken using a handheld probe. (b) Ultrasound (US)-guided breast imaging system with time-resolved diffuse optical spectroscopy (DOS). (c) The images present distribution of total hemoglobin (tHb) and tissue oxygen saturation (stO2) concentrations on both breasts. (d) A mediolateral oblique mammogram shows a round circumscribed mass (arrowhead) in the subareolar area. (e) A sagittal US image obtained at the 4 o'clock position in the left breast shows a lobulated hypoechoic shadowing mass (arrowhead). (f) Dynamic contrast-enhanced (DCE) MRI shows a solitary intensely enhancing mass (arrowhead) in the lower outer quadrant of the left breast. L, left; R, right.
Mentions: A region of interest (ROI)—a circle measuring 2 cm in radius—was assigned to the skin including the area of the lesion. The number of points included in an ROI was 10–14. We set the ROI showing the highest concentration of Hb. When we could not detect a hotspot, we set the ROI just above the lesion that was identified by US. We used the mean volume calculated from ROI analysis, automatically. The evaluation of Hb parameters was carried out as follows: tHb (μM) = O2Hb + HHb, stO2 (%) = O2Hb / tHb × 100, and rtHb = a ratio of tumor mean tHb to contralateral normal mean tHb. Figure 1 shows representative images of tHb and stO2 of both tumor-bearing and contralateral normal breast.

Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.

Show MeSH
Related in: MedlinePlus