Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.
Bottom Line: The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis .Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance.Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.
Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.Show MeSH
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Mentions: A region of interest (ROI)—a circle measuring 2 cm in radius—was assigned to the skin including the area of the lesion. The number of points included in an ROI was 10–14. We set the ROI showing the highest concentration of Hb. When we could not detect a hotspot, we set the ROI just above the lesion that was identified by US. We used the mean volume calculated from ROI analysis, automatically. The evaluation of Hb parameters was carried out as follows: tHb (μM) = O2Hb + HHb, stO2 (%) = O2Hb / tHb × 100, and rtHb = a ratio of tumor mean tHb to contralateral normal mean tHb. Figure 1 shows representative images of tHb and stO2 of both tumor-bearing and contralateral normal breast.
Affiliation: Department of Breast Oncology, International Medical Center, Saitama Medical University, Hidaka, Saitama.