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Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes.

Xu J, Alexander DB, Futakuchi M, Numano T, Fukamachi K, Suzui M, Omori T, Kanno J, Hirose A, Tsuda H - Cancer Sci. (2014)

Bottom Line: It was found that MWCNT-L, but not MWCNT-S, translocated into the pleural cavity, deposited in the parietal pleura, and induced fibrosis and patchy parietal mesothelial proliferation lesions.In contrast, MWCNT-S induced stronger inflammation and higher 8-hydroxydeoxyguanosine level in the lung tissue than MWCNT-L.These results suggest that MWCNT-L has higher risk of causing asbestos-like pleural lesions relevant to mesothelioma development.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Nanotoxicology Project, Nagoya City University, Nagoya, Japan; Department of Immunology, Anhui Medical University College of Basic Medical Sciences, Hefei, China.

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Evidence of multiwalled carbon nanotube (MWCNT) fibers in the pleura. Existence of MWCNT fibers in the parietal (a–c, g–i) and visceral (d–f, j–l) pleura of rats treated with larger sized MWCNT (MWCNT-L; l = 8 μm, d = 150 nm) (a–f) or smaller sized MWCNT (MWCNT-S; l = 3 μm, d = 15 nm) (g–l) was examined by polarized light microscopy (PLM) (d, e, h, k) and SEM (c, f, i, l). The area in (a) denoted by the square was subjected to SEM observation, shown in (c). Arrows indicate MWCNT fibers. PC, pleural cavity.
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fig01: Evidence of multiwalled carbon nanotube (MWCNT) fibers in the pleura. Existence of MWCNT fibers in the parietal (a–c, g–i) and visceral (d–f, j–l) pleura of rats treated with larger sized MWCNT (MWCNT-L; l = 8 μm, d = 150 nm) (a–f) or smaller sized MWCNT (MWCNT-S; l = 3 μm, d = 15 nm) (g–l) was examined by polarized light microscopy (PLM) (d, e, h, k) and SEM (c, f, i, l). The area in (a) denoted by the square was subjected to SEM observation, shown in (c). Arrows indicate MWCNT fibers. PC, pleural cavity.

Mentions: Observation of the pleural tissue sections with PLM and SEM indicated that MWCNT-L deposited in the parietal pleura in four out of six rats, most of the fibers being located in fibrotic parietal pleura, with a few piercing and penetrating into the parietal mesothelium (Fig. 1a–c); MWCNT-L was also found in the visceral pleura (Fig. 1d–f).


Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes.

Xu J, Alexander DB, Futakuchi M, Numano T, Fukamachi K, Suzui M, Omori T, Kanno J, Hirose A, Tsuda H - Cancer Sci. (2014)

Evidence of multiwalled carbon nanotube (MWCNT) fibers in the pleura. Existence of MWCNT fibers in the parietal (a–c, g–i) and visceral (d–f, j–l) pleura of rats treated with larger sized MWCNT (MWCNT-L; l = 8 μm, d = 150 nm) (a–f) or smaller sized MWCNT (MWCNT-S; l = 3 μm, d = 15 nm) (g–l) was examined by polarized light microscopy (PLM) (d, e, h, k) and SEM (c, f, i, l). The area in (a) denoted by the square was subjected to SEM observation, shown in (c). Arrows indicate MWCNT fibers. PC, pleural cavity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317921&req=5

fig01: Evidence of multiwalled carbon nanotube (MWCNT) fibers in the pleura. Existence of MWCNT fibers in the parietal (a–c, g–i) and visceral (d–f, j–l) pleura of rats treated with larger sized MWCNT (MWCNT-L; l = 8 μm, d = 150 nm) (a–f) or smaller sized MWCNT (MWCNT-S; l = 3 μm, d = 15 nm) (g–l) was examined by polarized light microscopy (PLM) (d, e, h, k) and SEM (c, f, i, l). The area in (a) denoted by the square was subjected to SEM observation, shown in (c). Arrows indicate MWCNT fibers. PC, pleural cavity.
Mentions: Observation of the pleural tissue sections with PLM and SEM indicated that MWCNT-L deposited in the parietal pleura in four out of six rats, most of the fibers being located in fibrotic parietal pleura, with a few piercing and penetrating into the parietal mesothelium (Fig. 1a–c); MWCNT-L was also found in the visceral pleura (Fig. 1d–f).

Bottom Line: It was found that MWCNT-L, but not MWCNT-S, translocated into the pleural cavity, deposited in the parietal pleura, and induced fibrosis and patchy parietal mesothelial proliferation lesions.In contrast, MWCNT-S induced stronger inflammation and higher 8-hydroxydeoxyguanosine level in the lung tissue than MWCNT-L.These results suggest that MWCNT-L has higher risk of causing asbestos-like pleural lesions relevant to mesothelioma development.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Nanotoxicology Project, Nagoya City University, Nagoya, Japan; Department of Immunology, Anhui Medical University College of Basic Medical Sciences, Hefei, China.

Show MeSH
Related in: MedlinePlus