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Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma.

Matsuwaki R, Ishii G, Zenke Y, Neri S, Aokage K, Hishida T, Yoshida J, Fujii S, Kondo H, Goya T, Nagai K, Ochiai A - Cancer Sci. (2014)

Bottom Line: Patients with mediastinal lymph node metastasis (N2) in squamous cell carcinoma (SqCC) of the lung have poor prognosis after surgical resection of the primary tumor.In the primary tumors, the expressions of all the examined molecules were not related to recurrence.Our study indicated that the immunophenotypes of both cancer cells and CAFs in metastatic lymph node tumors, but not primary tumors, provide useful information for predicting the recurrence of pathological N2 lung SqCC.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan; Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan; Division of Thoracic Surgery, Kyorin University, Tokyo, Japan.

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Immunohistochemical staining of tumor cells in a primary tumor and a metastatic lymph node tumor in a patient with squamous cell carcinoma of the lung. (a,b) Clusterin expression of cancer cells in the primary tumor (a) and the metastatic lymph node tumor (b). (c,d) ZEB2 expression of cancer cells in the primary tumor (c) and the metastatic lymph node tumor (d). (e,f) Podoplanin expression of cancer-associated fibroblasts in the primary tumor (e) and the metastatic lymph node tumor (f). Dotted lines show the margin of the cancer cell nest.
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fig02: Immunohistochemical staining of tumor cells in a primary tumor and a metastatic lymph node tumor in a patient with squamous cell carcinoma of the lung. (a,b) Clusterin expression of cancer cells in the primary tumor (a) and the metastatic lymph node tumor (b). (c,d) ZEB2 expression of cancer cells in the primary tumor (c) and the metastatic lymph node tumor (d). (e,f) Podoplanin expression of cancer-associated fibroblasts in the primary tumor (e) and the metastatic lymph node tumor (f). Dotted lines show the margin of the cancer cell nest.

Mentions: We carried out univariate analyses in the metastatic lymph node tumors (Table 4). A high clusterin expression level in cancer cells was observed in 24 cases (38%) (Fig. 2a,b). The 3-year RFS rate of cases with a high clusterin expression level was 28.6%, whereas that of cases with a low clusterin expression level was 45.2%. The difference between the two groups was significant (P = 0.04; Fig. 3a).


Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma.

Matsuwaki R, Ishii G, Zenke Y, Neri S, Aokage K, Hishida T, Yoshida J, Fujii S, Kondo H, Goya T, Nagai K, Ochiai A - Cancer Sci. (2014)

Immunohistochemical staining of tumor cells in a primary tumor and a metastatic lymph node tumor in a patient with squamous cell carcinoma of the lung. (a,b) Clusterin expression of cancer cells in the primary tumor (a) and the metastatic lymph node tumor (b). (c,d) ZEB2 expression of cancer cells in the primary tumor (c) and the metastatic lymph node tumor (d). (e,f) Podoplanin expression of cancer-associated fibroblasts in the primary tumor (e) and the metastatic lymph node tumor (f). Dotted lines show the margin of the cancer cell nest.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317916&req=5

fig02: Immunohistochemical staining of tumor cells in a primary tumor and a metastatic lymph node tumor in a patient with squamous cell carcinoma of the lung. (a,b) Clusterin expression of cancer cells in the primary tumor (a) and the metastatic lymph node tumor (b). (c,d) ZEB2 expression of cancer cells in the primary tumor (c) and the metastatic lymph node tumor (d). (e,f) Podoplanin expression of cancer-associated fibroblasts in the primary tumor (e) and the metastatic lymph node tumor (f). Dotted lines show the margin of the cancer cell nest.
Mentions: We carried out univariate analyses in the metastatic lymph node tumors (Table 4). A high clusterin expression level in cancer cells was observed in 24 cases (38%) (Fig. 2a,b). The 3-year RFS rate of cases with a high clusterin expression level was 28.6%, whereas that of cases with a low clusterin expression level was 45.2%. The difference between the two groups was significant (P = 0.04; Fig. 3a).

Bottom Line: Patients with mediastinal lymph node metastasis (N2) in squamous cell carcinoma (SqCC) of the lung have poor prognosis after surgical resection of the primary tumor.In the primary tumors, the expressions of all the examined molecules were not related to recurrence.Our study indicated that the immunophenotypes of both cancer cells and CAFs in metastatic lymph node tumors, but not primary tumors, provide useful information for predicting the recurrence of pathological N2 lung SqCC.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan; Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan; Division of Thoracic Surgery, Kyorin University, Tokyo, Japan.

Show MeSH
Related in: MedlinePlus