Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of the γδ phenotype from Japan.
Bottom Line: In addition, T-cell receptor (TCR) γδ cells are typically immunostained in frozen sections or determined by TCRβ negativity.Immunophenotypically, some significant differences were found in CD8 and CD56 positivity between our patient series of CTCL-γδ patients with SPTCL features and SPTCL-γδ patients described in the previous literature.Studies on more cases, including those from other countries, are warranted to delineate the clinicopathological features and the significance in these rare lymphomas.
Affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.Show MeSH
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Mentions: A summary of the immunohistochemical results is shown in Table 2. On the basis of TCRαβ and TCRγδ immunostaining, 17 patients were classified as CTCL-γδ. One patient expressed both TCRαβ and TCRγδ. Figures 1j,k,l and 2c,d show the immunohistochemical results for TCRγ, TCRδ and TCRβ immunostaining. Among all 17 patient samples, CD3 expression was positive in all but one sample (Figs 1c, 2b). Ten CTCL-γδ samples showed decreased or negative CD5 expression (Fig. 1d). Cytotoxic molecules (TIA-1 or granzyme B) were positive in all patient samples except 1 (Fig. 1 h,i). CD56 expression was negative except in two patient samples (Fig. 1e). In addition, we demonstrated SPTCL, which was positive for TCRαβ and negative for TCRγδ (Fig. 3).
Affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.