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Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of the γδ phenotype from Japan.

Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, Hashimoto K, Tashiro Y, Takeuchi S, Masunari T, Hiramatsu Y, Maeda Y, Tanimoto M, Yoshino T - Cancer Sci. (2014)

Bottom Line: In addition, T-cell receptor (TCR) γδ cells are typically immunostained in frozen sections or determined by TCRβ negativity.Immunophenotypically, some significant differences were found in CD8 and CD56 positivity between our patient series of CTCL-γδ patients with SPTCL features and SPTCL-γδ patients described in the previous literature.Studies on more cases, including those from other countries, are warranted to delineate the clinicopathological features and the significance in these rare lymphomas.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

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Related in: MedlinePlus

Immunostainings of primary cutaneous T-cell lymphoma of the γδ phenotype without subcutanous panniculitis-like T-cell lymphoma feature in patient no. 4 (b–e: original magnification ×20 objective). (a) High-power field of cutaneous tumor reveals medium to large sized neoplastic cells infiltrating diffusely (H&E). (b–d) Immunohistochemical results. The lymphoid cells were positive for CD3 (b), positive for T-cell receptor (TCR) γ (c) and negative for TCRβ (d).
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fig02: Immunostainings of primary cutaneous T-cell lymphoma of the γδ phenotype without subcutanous panniculitis-like T-cell lymphoma feature in patient no. 4 (b–e: original magnification ×20 objective). (a) High-power field of cutaneous tumor reveals medium to large sized neoplastic cells infiltrating diffusely (H&E). (b–d) Immunohistochemical results. The lymphoid cells were positive for CD3 (b), positive for T-cell receptor (TCR) γ (c) and negative for TCRβ (d).

Mentions: Of all 17 CTCL-γδ patient samples, six presented histological patterns similar to those of SPTCL and 11 presented histologically non-SPTCL features (Figs 1a,b, 2a). The macroscopic and microscopic features of 17 CTCL-γδ patient lesions are shown in Table 1. All six CTCL-γδ with SPTCL patients present as plaques while 11 CTCL-γδ without SPTCL patients present as patches, plaques and tumors. Of the six CTCL-γδ with STPCL features, karyorrhexis was observed in all patient samples, necrosis in three, and ulcer and vascular invasion of small blood vessels in one. Of the 11 samples from CTCL-γδ patients without SPTCL features, three presented both superficial and deep dermal lesions, and seven samples showed partial subcutaneous involvement. Ulcer, epidermotropism and angioinvasion were observed in three patient samples, and necrosis in two. The neoplastic cells were medium to large in size, with coarsely clumped chromatin deposition (Fig. 2a).


Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of the γδ phenotype from Japan.

Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, Hashimoto K, Tashiro Y, Takeuchi S, Masunari T, Hiramatsu Y, Maeda Y, Tanimoto M, Yoshino T - Cancer Sci. (2014)

Immunostainings of primary cutaneous T-cell lymphoma of the γδ phenotype without subcutanous panniculitis-like T-cell lymphoma feature in patient no. 4 (b–e: original magnification ×20 objective). (a) High-power field of cutaneous tumor reveals medium to large sized neoplastic cells infiltrating diffusely (H&E). (b–d) Immunohistochemical results. The lymphoid cells were positive for CD3 (b), positive for T-cell receptor (TCR) γ (c) and negative for TCRβ (d).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317912&req=5

fig02: Immunostainings of primary cutaneous T-cell lymphoma of the γδ phenotype without subcutanous panniculitis-like T-cell lymphoma feature in patient no. 4 (b–e: original magnification ×20 objective). (a) High-power field of cutaneous tumor reveals medium to large sized neoplastic cells infiltrating diffusely (H&E). (b–d) Immunohistochemical results. The lymphoid cells were positive for CD3 (b), positive for T-cell receptor (TCR) γ (c) and negative for TCRβ (d).
Mentions: Of all 17 CTCL-γδ patient samples, six presented histological patterns similar to those of SPTCL and 11 presented histologically non-SPTCL features (Figs 1a,b, 2a). The macroscopic and microscopic features of 17 CTCL-γδ patient lesions are shown in Table 1. All six CTCL-γδ with SPTCL patients present as plaques while 11 CTCL-γδ without SPTCL patients present as patches, plaques and tumors. Of the six CTCL-γδ with STPCL features, karyorrhexis was observed in all patient samples, necrosis in three, and ulcer and vascular invasion of small blood vessels in one. Of the 11 samples from CTCL-γδ patients without SPTCL features, three presented both superficial and deep dermal lesions, and seven samples showed partial subcutaneous involvement. Ulcer, epidermotropism and angioinvasion were observed in three patient samples, and necrosis in two. The neoplastic cells were medium to large in size, with coarsely clumped chromatin deposition (Fig. 2a).

Bottom Line: In addition, T-cell receptor (TCR) γδ cells are typically immunostained in frozen sections or determined by TCRβ negativity.Immunophenotypically, some significant differences were found in CD8 and CD56 positivity between our patient series of CTCL-γδ patients with SPTCL features and SPTCL-γδ patients described in the previous literature.Studies on more cases, including those from other countries, are warranted to delineate the clinicopathological features and the significance in these rare lymphomas.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Show MeSH
Related in: MedlinePlus