Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
Bottom Line: Clonal heterogeneity in lymphoid malignancies has been recently reported in adult T-cell lymphoma/leukemia, peripheral T-cell lymphoma, not otherwise specified, and mantle cell lymphoma.Survival analysis revealed that mantle cell lymphoma and diffuse large B-cell lymphoma with clonal heterogeneity showed significantly poorer prognosis, and that clonal heterogeneity was confirmed as an independent predictor of poor prognosis for both types of lymphoma.Interestingly, 8q24.1 (MYC) gain, 9p21.3 (CDKN2A/2B) loss and 17p13 (TP53, ATP1B2, SAT2, SHBG) loss were recurrent genomic lesions among various types of lymphoma with clonal heterogeneity, suggesting at least in part that alterations of these genes may play a role in clonal heterogeneity.
Affiliation: Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.Show MeSH
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Mentions: We defined a case indicating the same log2 ratio for all CNA as a sample without clonal heterogeneity (Fig. 1a) because the single tumor cell population was calculated from the log2 ratio(s) of all CNA in this sample. We defined a case having different log2 ratios in one sample as a sample with clonal heterogeneity (Fig. 1a). Differences in log2 ratios were evaluated using Student's t-test (P < 0.001) as previously described.(9) In a few cases, the same tumor cell population was applied when the log2 ratios were proportional at variable copy numbers (one copy gain versus two copy gain) in the same sample. For example, a log2 ratio of 0.685 indicates a tumor cell population of 61% in a case of one copy gain and 0.39 is 63% in two copy gain (Fig. S1d). We defined such a case with different log2 ratios showing one tumor cell population as a sample without clonal heterogeneity.
Affiliation: Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.