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Capn4 is a marker of poor clinical outcomes and promotes nasopharyngeal carcinoma metastasis via nuclear factor-κB-induced matrix metalloproteinase 2 expression.

Zheng PC, Chen X, Zhu HW, Zheng W, Mao LH, Lin C, Liu JN, Zheng M - Cancer Sci. (2014)

Bottom Line: The patients with NPC displaying higher Capn4 had a significantly shorter overall survival (P = 0.002) and progression-free survival (P = 0.003).These events resulted from Capn4 downregulation were associated with reduced expression of matrix metalloproteinase 2 (MMP2), Snail, and Vimentin.Together, these findings argue a novel function of Capn4 in invasion and metastasis of NPC, and thereby suggest that Capn4 may represent an independent prognostic factor and a potential therapeutic target in NPC.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

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Expression of Capn4 is correlated with overall survival of patients with nasopharyngeal carcinoma (NPC). (a) Capn4 expression, reflected by staining intensity, in tumor and normal tissues were evaluated by IHC. 1 and 2, normal tissues; 3 and 4, NPC tumor tissues. (b, c) Kaplan–Meier analysis of overall survival (b) or progression-free survival (c) in 153 patients with NPC, stratified by Capn4 levels.
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fig02: Expression of Capn4 is correlated with overall survival of patients with nasopharyngeal carcinoma (NPC). (a) Capn4 expression, reflected by staining intensity, in tumor and normal tissues were evaluated by IHC. 1 and 2, normal tissues; 3 and 4, NPC tumor tissues. (b, c) Kaplan–Meier analysis of overall survival (b) or progression-free survival (c) in 153 patients with NPC, stratified by Capn4 levels.

Mentions: To confirm the RT-PCR and Western blot results, we next dete-cted expression of Capn4 protein in archived paraffin-embedded NPC tumor and non-tumoral nasopharyngeal specimens by immunohistochemical staining. Whereas Capn4-specific staining was observed in both non-cancerous and malignant tissues, primarily localized in the cytoplasm of cells (Fig.2a), expression levels of Capn4 in NPC samples were significantly higher than that in non-tumoral tissues (P < 0.001; Table1).


Capn4 is a marker of poor clinical outcomes and promotes nasopharyngeal carcinoma metastasis via nuclear factor-κB-induced matrix metalloproteinase 2 expression.

Zheng PC, Chen X, Zhu HW, Zheng W, Mao LH, Lin C, Liu JN, Zheng M - Cancer Sci. (2014)

Expression of Capn4 is correlated with overall survival of patients with nasopharyngeal carcinoma (NPC). (a) Capn4 expression, reflected by staining intensity, in tumor and normal tissues were evaluated by IHC. 1 and 2, normal tissues; 3 and 4, NPC tumor tissues. (b, c) Kaplan–Meier analysis of overall survival (b) or progression-free survival (c) in 153 patients with NPC, stratified by Capn4 levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317905&req=5

fig02: Expression of Capn4 is correlated with overall survival of patients with nasopharyngeal carcinoma (NPC). (a) Capn4 expression, reflected by staining intensity, in tumor and normal tissues were evaluated by IHC. 1 and 2, normal tissues; 3 and 4, NPC tumor tissues. (b, c) Kaplan–Meier analysis of overall survival (b) or progression-free survival (c) in 153 patients with NPC, stratified by Capn4 levels.
Mentions: To confirm the RT-PCR and Western blot results, we next dete-cted expression of Capn4 protein in archived paraffin-embedded NPC tumor and non-tumoral nasopharyngeal specimens by immunohistochemical staining. Whereas Capn4-specific staining was observed in both non-cancerous and malignant tissues, primarily localized in the cytoplasm of cells (Fig.2a), expression levels of Capn4 in NPC samples were significantly higher than that in non-tumoral tissues (P < 0.001; Table1).

Bottom Line: The patients with NPC displaying higher Capn4 had a significantly shorter overall survival (P = 0.002) and progression-free survival (P = 0.003).These events resulted from Capn4 downregulation were associated with reduced expression of matrix metalloproteinase 2 (MMP2), Snail, and Vimentin.Together, these findings argue a novel function of Capn4 in invasion and metastasis of NPC, and thereby suggest that Capn4 may represent an independent prognostic factor and a potential therapeutic target in NPC.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Show MeSH
Related in: MedlinePlus