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Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection.

Yoshiya S, Fujimoto Y, Bekki Y, Konishi H, Yamashita Y, Ikegami T, Yoshizumi T, Shirabe K, Oda Y, Maehara Y - Cancer Sci. (2014)

Bottom Line: Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors.The AA group had significantly higher recurrence-free survival than the AG/GG group (P = 0.04), but there was no significant difference in overall survival between these two groups (P = 0.97).High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival (P = 0.37) or recurrence-free survival (P = 0.39).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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Immunohistochemical staining of resected liver tissues for epidermal growth factor receptor (EGFR) (original magnification ×400). (a) Cancer cells showing EGFR expression in the cytoplasm and cell membranes. (b) Non-cancerous hepatocytes, showing EGFR expression in the cytoplasm. (c,d) Associations between immunoreactivity scores for EGFR and prognosis after hepatectomy. There were no significant differences in overall survival or recurrence-free survival rates between patients with high and low scores (P = 0.37 and P = 0.39, respectively).
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fig03: Immunohistochemical staining of resected liver tissues for epidermal growth factor receptor (EGFR) (original magnification ×400). (a) Cancer cells showing EGFR expression in the cytoplasm and cell membranes. (b) Non-cancerous hepatocytes, showing EGFR expression in the cytoplasm. (c,d) Associations between immunoreactivity scores for EGFR and prognosis after hepatectomy. There were no significant differences in overall survival or recurrence-free survival rates between patients with high and low scores (P = 0.37 and P = 0.39, respectively).

Mentions: Immunohistochemical analysis showed that EGFR was expressed in the cytoplasm and cell membranes of HCC cells (Fig.3a), and that the intensity of staining in the cytoplasm correlated with that of the cell membranes. Patients were divided into a high score group (immunoreactivity score >5, n = 38) and a low score group (immunoreactivity score ≤5, n = 103). Table3 shows comparisons of clinicopathological factors between these two groups. Univariate analyses showed that the high score group had a significant higher preoperative serum alanine aminotransferase level (67 ± 47 IU/L vs 52 ± 38 IU/L, P = 0.04), lower des-gamma-carboxy prothrombin level (1.78 ± 0.74 log mAU/mL vs 2.14 ± 1.00 log mAU/mL, P = 0.04) and smaller maximum tumor size (2.8 ± 1.5 cm vs 3.8 ± 2.7 cm, P = 0.04) than the low score group. There were no significant differences in OS or RFS between the high and low score groups (P = 0.37 and P = 0.39, respectively; Fig.3c,d).


Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection.

Yoshiya S, Fujimoto Y, Bekki Y, Konishi H, Yamashita Y, Ikegami T, Yoshizumi T, Shirabe K, Oda Y, Maehara Y - Cancer Sci. (2014)

Immunohistochemical staining of resected liver tissues for epidermal growth factor receptor (EGFR) (original magnification ×400). (a) Cancer cells showing EGFR expression in the cytoplasm and cell membranes. (b) Non-cancerous hepatocytes, showing EGFR expression in the cytoplasm. (c,d) Associations between immunoreactivity scores for EGFR and prognosis after hepatectomy. There were no significant differences in overall survival or recurrence-free survival rates between patients with high and low scores (P = 0.37 and P = 0.39, respectively).
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4317904&req=5

fig03: Immunohistochemical staining of resected liver tissues for epidermal growth factor receptor (EGFR) (original magnification ×400). (a) Cancer cells showing EGFR expression in the cytoplasm and cell membranes. (b) Non-cancerous hepatocytes, showing EGFR expression in the cytoplasm. (c,d) Associations between immunoreactivity scores for EGFR and prognosis after hepatectomy. There were no significant differences in overall survival or recurrence-free survival rates between patients with high and low scores (P = 0.37 and P = 0.39, respectively).
Mentions: Immunohistochemical analysis showed that EGFR was expressed in the cytoplasm and cell membranes of HCC cells (Fig.3a), and that the intensity of staining in the cytoplasm correlated with that of the cell membranes. Patients were divided into a high score group (immunoreactivity score >5, n = 38) and a low score group (immunoreactivity score ≤5, n = 103). Table3 shows comparisons of clinicopathological factors between these two groups. Univariate analyses showed that the high score group had a significant higher preoperative serum alanine aminotransferase level (67 ± 47 IU/L vs 52 ± 38 IU/L, P = 0.04), lower des-gamma-carboxy prothrombin level (1.78 ± 0.74 log mAU/mL vs 2.14 ± 1.00 log mAU/mL, P = 0.04) and smaller maximum tumor size (2.8 ± 1.5 cm vs 3.8 ± 2.7 cm, P = 0.04) than the low score group. There were no significant differences in OS or RFS between the high and low score groups (P = 0.37 and P = 0.39, respectively; Fig.3c,d).

Bottom Line: Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors.The AA group had significantly higher recurrence-free survival than the AG/GG group (P = 0.04), but there was no significant difference in overall survival between these two groups (P = 0.97).High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival (P = 0.37) or recurrence-free survival (P = 0.39).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Show MeSH
Related in: MedlinePlus