Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection.
Bottom Line: Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors.The AA group had significantly higher recurrence-free survival than the AG/GG group (P = 0.04), but there was no significant difference in overall survival between these two groups (P = 0.97).High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival (P = 0.37) or recurrence-free survival (P = 0.39).
Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Show MeSH
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Mentions: Immunohistochemical analysis showed that EGFR was expressed in the cytoplasm and cell membranes of HCC cells (Fig.3a), and that the intensity of staining in the cytoplasm correlated with that of the cell membranes. Patients were divided into a high score group (immunoreactivity score >5, n = 38) and a low score group (immunoreactivity score ≤5, n = 103). Table3 shows comparisons of clinicopathological factors between these two groups. Univariate analyses showed that the high score group had a significant higher preoperative serum alanine aminotransferase level (67 ± 47 IU/L vs 52 ± 38 IU/L, P = 0.04), lower des-gamma-carboxy prothrombin level (1.78 ± 0.74 log mAU/mL vs 2.14 ± 1.00 log mAU/mL, P = 0.04) and smaller maximum tumor size (2.8 ± 1.5 cm vs 3.8 ± 2.7 cm, P = 0.04) than the low score group. There were no significant differences in OS or RFS between the high and low score groups (P = 0.37 and P = 0.39, respectively; Fig.3c,d).
Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.