Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection.
Bottom Line: Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors.The AA group had significantly higher recurrence-free survival than the AG/GG group (P = 0.04), but there was no significant difference in overall survival between these two groups (P = 0.97).High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival (P = 0.37) or recurrence-free survival (P = 0.39).
Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Show MeSH
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Mentions: The serum EGF concentration was 47.9 ± 34.6 pg/mL in patients carrying GG, 36.8 ± 21.9 pg/mL in patients carrying AG, and 26.3 ± 15.9 pg/mL in patients carrying AA (P = 0.01; Fig.2a). The AA group had a significantly lower serum EGF concentration than the AG/GG group (26.3 ± 15.9 pg/mL vs 43.4 ± 30.5 pg/mL, P = 0.02; Fig.2b). Recurrence was divided into early type (within 2 years after surgery) and late type. The AA group had a significantly lower proportion of early type recurrence than the AG/GG group (28.6% vs 71.2%, P = 0.03, Table2).
Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.