Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection.
Bottom Line: Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors.The AA group had significantly higher recurrence-free survival than the AG/GG group (P = 0.04), but there was no significant difference in overall survival between these two groups (P = 0.97).High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival (P = 0.37) or recurrence-free survival (P = 0.39).
Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Show MeSH
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Mentions: There were no significant differences in OS or RFS among patients carrying the AA, AG and GG alleles (P = 0.99 and P = 0.11, respectively; Fig.1a,b). There was no significant difference in OS between the AA group (n = 16) and the AG/GG group (n = 125) (P = 0.97; Fig.1c), but RFS was significantly higher in the AA group than in the AG/GG group (P = 0.04; Fig.1d).
Affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.