Limits...
LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer.

Liang XH, Zhang GX, Zeng YB, Yang HF, Li WH, Liu QL, Tang YL, He WG, Huang YN, Zhang L, Yu LN, Zeng XC - Cancer Sci. (2014)

Bottom Line: Here, we found that JUB, but not the other Ajuba family proteins, was highly upregulated in clinical specimens and CRC cell lines.The expression of JUB shows an inverse correlation with E-cadherin expression in clinical specimens.Thus, the LIM protein JUB may provide a novel target for therapy of metastatic CRC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.

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Reverse correlated expression between JUB and E-cadherin in clinical specimens. (a) Western blot analysis of JUB and E-cadherin in clinical specimens. (b) Quantification and Pearson correlation statistical analyzing of JUB and E-cadherin expression.
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fig05: Reverse correlated expression between JUB and E-cadherin in clinical specimens. (a) Western blot analysis of JUB and E-cadherin in clinical specimens. (b) Quantification and Pearson correlation statistical analyzing of JUB and E-cadherin expression.

Mentions: Finally, we examined whether JUB repressing E-cadherin expression to induce EMT identified in CRC cells is also evident in clinical CRC specimens. By analyzing 10 cases of freshly collected CRC tissue specimens, we found that specimens with higher expression of JUB showed lower expression of E-cadherin (Fig. 5a). Quantification and correlation analysis proved that expression of E-cadherin and JUB significantly correlated, inversely (r = −0.649, P = 0.042, Fig.5(b).


LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer.

Liang XH, Zhang GX, Zeng YB, Yang HF, Li WH, Liu QL, Tang YL, He WG, Huang YN, Zhang L, Yu LN, Zeng XC - Cancer Sci. (2014)

Reverse correlated expression between JUB and E-cadherin in clinical specimens. (a) Western blot analysis of JUB and E-cadherin in clinical specimens. (b) Quantification and Pearson correlation statistical analyzing of JUB and E-cadherin expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317901&req=5

fig05: Reverse correlated expression between JUB and E-cadherin in clinical specimens. (a) Western blot analysis of JUB and E-cadherin in clinical specimens. (b) Quantification and Pearson correlation statistical analyzing of JUB and E-cadherin expression.
Mentions: Finally, we examined whether JUB repressing E-cadherin expression to induce EMT identified in CRC cells is also evident in clinical CRC specimens. By analyzing 10 cases of freshly collected CRC tissue specimens, we found that specimens with higher expression of JUB showed lower expression of E-cadherin (Fig. 5a). Quantification and correlation analysis proved that expression of E-cadherin and JUB significantly correlated, inversely (r = −0.649, P = 0.042, Fig.5(b).

Bottom Line: Here, we found that JUB, but not the other Ajuba family proteins, was highly upregulated in clinical specimens and CRC cell lines.The expression of JUB shows an inverse correlation with E-cadherin expression in clinical specimens.Thus, the LIM protein JUB may provide a novel target for therapy of metastatic CRC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.

Show MeSH
Related in: MedlinePlus