LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer.
Bottom Line: Here, we found that JUB, but not the other Ajuba family proteins, was highly upregulated in clinical specimens and CRC cell lines.The expression of JUB shows an inverse correlation with E-cadherin expression in clinical specimens.Thus, the LIM protein JUB may provide a novel target for therapy of metastatic CRC.
Affiliation: Department of Gastroenterology, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.Show MeSH
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Mentions: Finally, we examined whether JUB repressing E-cadherin expression to induce EMT identified in CRC cells is also evident in clinical CRC specimens. By analyzing 10 cases of freshly collected CRC tissue specimens, we found that specimens with higher expression of JUB showed lower expression of E-cadherin (Fig. 5a). Quantification and correlation analysis proved that expression of E-cadherin and JUB significantly correlated, inversely (r = −0.649, P = 0.042, Fig.5(b).
Affiliation: Department of Gastroenterology, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.