Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma.
Bottom Line: Patients in the high-STMN1-expression group were associated with shorter recurrence-free survival and overall survival than those in the low-expression group.STMN1 knockdown inhibited proliferation and increased the sensitivity of EHCC cells to paclitaxel.Understanding the regulation of p27 by STMN1 could provide new insights for overcoming therapeutic resistance in EHCC.
Affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.Show MeSH
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Mentions: To examine the protein complexes of STMN1 and p27 in HuCCT1 cells, we performed PLA, which revealed the complexes as red spots in the cytoplasm (Fig.3a). Thus, STMN1 interacts with p27 in the cytoplasm, but not in the nucleus, of EHCC cells.
Affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.