Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma.
Bottom Line: Patients in the high-STMN1-expression group were associated with shorter recurrence-free survival and overall survival than those in the low-expression group.STMN1 knockdown inhibited proliferation and increased the sensitivity of EHCC cells to paclitaxel.Understanding the regulation of p27 by STMN1 could provide new insights for overcoming therapeutic resistance in EHCC.
Affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.Show MeSH
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Mentions: The prognostic significance of STMN1 expression on postoperative recurrence-free survival (RFS) and cancer-specific survival (CSS) is shown in Figure2. The STMN1-positive group had significantly poorer prognoses than the STMN1-negative group, regarding both RFS (P = 0.0222) and CSS (P = 0.0061). For CSS, STMN1 expression was prognostic for poor survival in the univariate analysis (Table2; P = 0.0044). Multivariate analysis also showed STMN1 expression is prognostic for poor survival (Table2; P = 0.0165). Interestingly, other existing clinicopathological factors were not significantly and independently associated with shorter CSS, whereas STMN1 expression in EHCC remained more significant than the presence of lymph node metastasis (Table2; hazard ratio [HR], 1.696; 95% confidence interval [CI], 1.10–2.76).
Affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.