Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma.
Bottom Line: Patients in the high-STMN1-expression group were associated with shorter recurrence-free survival and overall survival than those in the low-expression group.STMN1 knockdown inhibited proliferation and increased the sensitivity of EHCC cells to paclitaxel.Understanding the regulation of p27 by STMN1 could provide new insights for overcoming therapeutic resistance in EHCC.
Affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.Show MeSH
Related in: MedlinePlus
Mentions: STMN1 expression was evaluated using immunohistochemistry in 80 EHCC samples. Thirty-three samples (41.2%) were negative for STMN1 expression (Fig.1a) and 47 samples (58.8%) were positive for cytoplasmic STMN1 expression (Fig.1b). Nuclear p27 expression was also evaluated in these samples. Twenty-five (31.2%) samples were positive for p27 expression (Fig.1c) and 55 samples (68.8%) were negative (Fig.1d). High STMN1 expression was associated with low p27 nuclear expression (P = 0.0011; Table1). Cytoplasmic p27 expression was evaluated in the same EHCC samples; 43 (54.4%) samples demonstrated high cytoplasmic staining for p27 expression (Fig.1d), whereas 36 (45.6%) samples exhibited low p27 expression (Fig.1c). High STMN1 expression was associated with high p27 cytoplasmic expression (P = 0.0063; Table1).
Affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.