Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer.
Bottom Line: Downregulation of DAB2IP could activate the ERK and Akt pathways and was correlated with the expression of epithelial-mesenchymal transition markers, such as E-cadherin and vimentin.In conclusion, downregulation of DAB2IP is associated with features of biologically aggressive UCB and results in cell proliferation, migration, and invasion of bladder cancer.DAB2IP may serve as a promising biomarker in patients with UCB treated by radical cystectomy and bilateral lymph node dissection.
Affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.Show MeSH
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Mentions: We further examined the relationship between DAB2IP expression and EMT markers including E-cadherin and vimentin using human bladder specimens. Low expression of DAB2IP and E-cadherin as well as increased expression of vimentin were clearly detected in tissues from bladder cancer patients (Fig.6). There was a significant correlation between the levels of DAB2IP and E-cadherin (r = 0.817) and an inverse correlation between the levels of DAB2IP and vimentin (r = 0.666) in the tested samples (Table5).
Affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.