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Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer.

Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW - Cancer Sci. (2014)

Bottom Line: Downregulation of DAB2IP could activate the ERK and Akt pathways and was correlated with the expression of epithelial-mesenchymal transition markers, such as E-cadherin and vimentin.In conclusion, downregulation of DAB2IP is associated with features of biologically aggressive UCB and results in cell proliferation, migration, and invasion of bladder cancer.DAB2IP may serve as a promising biomarker in patients with UCB treated by radical cystectomy and bilateral lymph node dissection.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

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Expression of DOC-2/DAB2 interactive protein (DAB2IP) and epithelial–mesenchymal transition markers in urothelial carcinoma of the bladder (UCB) and normal bladder urothelium by immunohistochemistry. High expression of DAB2IP (a) and E-cadherin (b) but low expression of vimentin (c) is evident in normal bladder urothelium (magnification, ×100). Similarly, high expression of DAB2IP (d) and E-cadherin (e) but low expression of vimentin (f) is evident in low-grade UCB tissue (×100). However, low expression of DAB2IP (g) and E-cadherin (h) but high expression of vimentin (i) is evident in high-grade UCB tissue (×100).
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fig06: Expression of DOC-2/DAB2 interactive protein (DAB2IP) and epithelial–mesenchymal transition markers in urothelial carcinoma of the bladder (UCB) and normal bladder urothelium by immunohistochemistry. High expression of DAB2IP (a) and E-cadherin (b) but low expression of vimentin (c) is evident in normal bladder urothelium (magnification, ×100). Similarly, high expression of DAB2IP (d) and E-cadherin (e) but low expression of vimentin (f) is evident in low-grade UCB tissue (×100). However, low expression of DAB2IP (g) and E-cadherin (h) but high expression of vimentin (i) is evident in high-grade UCB tissue (×100).

Mentions: We further examined the relationship between DAB2IP expression and EMT markers including E-cadherin and vimentin using human bladder specimens. Low expression of DAB2IP and E-cadherin as well as increased expression of vimentin were clearly detected in tissues from bladder cancer patients (Fig.6). There was a significant correlation between the levels of DAB2IP and E-cadherin (r = 0.817) and an inverse correlation between the levels of DAB2IP and vimentin (r = 0.666) in the tested samples (Table5).


Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer.

Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW - Cancer Sci. (2014)

Expression of DOC-2/DAB2 interactive protein (DAB2IP) and epithelial–mesenchymal transition markers in urothelial carcinoma of the bladder (UCB) and normal bladder urothelium by immunohistochemistry. High expression of DAB2IP (a) and E-cadherin (b) but low expression of vimentin (c) is evident in normal bladder urothelium (magnification, ×100). Similarly, high expression of DAB2IP (d) and E-cadherin (e) but low expression of vimentin (f) is evident in low-grade UCB tissue (×100). However, low expression of DAB2IP (g) and E-cadherin (h) but high expression of vimentin (i) is evident in high-grade UCB tissue (×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317890&req=5

fig06: Expression of DOC-2/DAB2 interactive protein (DAB2IP) and epithelial–mesenchymal transition markers in urothelial carcinoma of the bladder (UCB) and normal bladder urothelium by immunohistochemistry. High expression of DAB2IP (a) and E-cadherin (b) but low expression of vimentin (c) is evident in normal bladder urothelium (magnification, ×100). Similarly, high expression of DAB2IP (d) and E-cadherin (e) but low expression of vimentin (f) is evident in low-grade UCB tissue (×100). However, low expression of DAB2IP (g) and E-cadherin (h) but high expression of vimentin (i) is evident in high-grade UCB tissue (×100).
Mentions: We further examined the relationship between DAB2IP expression and EMT markers including E-cadherin and vimentin using human bladder specimens. Low expression of DAB2IP and E-cadherin as well as increased expression of vimentin were clearly detected in tissues from bladder cancer patients (Fig.6). There was a significant correlation between the levels of DAB2IP and E-cadherin (r = 0.817) and an inverse correlation between the levels of DAB2IP and vimentin (r = 0.666) in the tested samples (Table5).

Bottom Line: Downregulation of DAB2IP could activate the ERK and Akt pathways and was correlated with the expression of epithelial-mesenchymal transition markers, such as E-cadherin and vimentin.In conclusion, downregulation of DAB2IP is associated with features of biologically aggressive UCB and results in cell proliferation, migration, and invasion of bladder cancer.DAB2IP may serve as a promising biomarker in patients with UCB treated by radical cystectomy and bilateral lymph node dissection.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Show MeSH
Related in: MedlinePlus