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Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer.

Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW - Cancer Sci. (2014)

Bottom Line: Downregulation of DAB2IP could activate the ERK and Akt pathways and was correlated with the expression of epithelial-mesenchymal transition markers, such as E-cadherin and vimentin.In conclusion, downregulation of DAB2IP is associated with features of biologically aggressive UCB and results in cell proliferation, migration, and invasion of bladder cancer.DAB2IP may serve as a promising biomarker in patients with UCB treated by radical cystectomy and bilateral lymph node dissection.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

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Expression of DOC-2/DAB2 interactive protein (DAB2IP) in urothelial carcinoma of the bladder (UCB) tissues and bladder urothelium controls by immunohistochemistry. (a) High expression of DAB2IP in normal bladder urothelium scored as 7 (magnification, ×200). (b) High expression of DAB2IP in low-grade UCB tissue scored as 5 (×200). (c) Low expression of DAB2IP in high-grade UCB tissue scored as 2 (×200). (d) Low expression of DAB2IP in high-grade UCB tissue scored as 0 (×200).
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fig01: Expression of DOC-2/DAB2 interactive protein (DAB2IP) in urothelial carcinoma of the bladder (UCB) tissues and bladder urothelium controls by immunohistochemistry. (a) High expression of DAB2IP in normal bladder urothelium scored as 7 (magnification, ×200). (b) High expression of DAB2IP in low-grade UCB tissue scored as 5 (×200). (c) Low expression of DAB2IP in high-grade UCB tissue scored as 2 (×200). (d) Low expression of DAB2IP in high-grade UCB tissue scored as 0 (×200).

Mentions: Expression of DAB2IP was noted mainly in the cytoplasm of bladder urothelial cells. When positive, intensity of DAB2IP positivity in cells ranged from 1 to 7, and it was diffuse (Fig.1). Of all UCB tissues, 72.6% (98/135) showed low expression of DAB2IP, whereas only 16.7% (5/30) bladder urothelium controls did (χ² = 32.9, P < 0.0001; Table1).


Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer.

Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW - Cancer Sci. (2014)

Expression of DOC-2/DAB2 interactive protein (DAB2IP) in urothelial carcinoma of the bladder (UCB) tissues and bladder urothelium controls by immunohistochemistry. (a) High expression of DAB2IP in normal bladder urothelium scored as 7 (magnification, ×200). (b) High expression of DAB2IP in low-grade UCB tissue scored as 5 (×200). (c) Low expression of DAB2IP in high-grade UCB tissue scored as 2 (×200). (d) Low expression of DAB2IP in high-grade UCB tissue scored as 0 (×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317890&req=5

fig01: Expression of DOC-2/DAB2 interactive protein (DAB2IP) in urothelial carcinoma of the bladder (UCB) tissues and bladder urothelium controls by immunohistochemistry. (a) High expression of DAB2IP in normal bladder urothelium scored as 7 (magnification, ×200). (b) High expression of DAB2IP in low-grade UCB tissue scored as 5 (×200). (c) Low expression of DAB2IP in high-grade UCB tissue scored as 2 (×200). (d) Low expression of DAB2IP in high-grade UCB tissue scored as 0 (×200).
Mentions: Expression of DAB2IP was noted mainly in the cytoplasm of bladder urothelial cells. When positive, intensity of DAB2IP positivity in cells ranged from 1 to 7, and it was diffuse (Fig.1). Of all UCB tissues, 72.6% (98/135) showed low expression of DAB2IP, whereas only 16.7% (5/30) bladder urothelium controls did (χ² = 32.9, P < 0.0001; Table1).

Bottom Line: Downregulation of DAB2IP could activate the ERK and Akt pathways and was correlated with the expression of epithelial-mesenchymal transition markers, such as E-cadherin and vimentin.In conclusion, downregulation of DAB2IP is associated with features of biologically aggressive UCB and results in cell proliferation, migration, and invasion of bladder cancer.DAB2IP may serve as a promising biomarker in patients with UCB treated by radical cystectomy and bilateral lymph node dissection.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Show MeSH
Related in: MedlinePlus