p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors.
Bottom Line: High p53 expression was positively correlated with tumor grade, HER2 score and Ki-67 expression.Significant association was observed between disease-free survival and high p53 expression in multivariate analysis (P < 0.0001).Compared with women without recurrence, women with early recurrence had significantly higher p53 expression (P < 0.0001), as did women with late recurrence (P = 0.037).
Affiliation: Breast and Endocrine Surgery, Hokkaido University Hospital, Sapporo, Japan.Show MeSH
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Mentions: We first analyzed p53 expression by immunohistochemistry in a selection of cancer cell lines using formalin-fixed, paraffin-embedded cell block materials (Table2, Fig.2). Negative or week nuclear staining in only a few cells was observed in H1299 p53 cells and in H2228, Lovo, Hela and MCF-7 cells without the TP53 gene mutation (Fig.2, upper panel). In contrast, strong nuclear staining in all cells was seen in T47D, SK-BR-3, BT-474, MDA-MB-231 and MDA-MB-468 cells with missense mutations of the TP53 gene (Fig.2, lower panel).
Affiliation: Breast and Endocrine Surgery, Hokkaido University Hospital, Sapporo, Japan.