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Polymorphisms of EpCAM gene and prognosis for non-small-cell lung cancer in Han Chinese.

Yang Y, Fei F, Song Y, Li X, Zhang Z, Fei Z, Su H, Wan S - Cancer Sci. (2013)

Bottom Line: The epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide variety of human cancers and is associated with patient prognosis, including those with lung cancer.We found that the non-synonymous SNP rs1126497 was significantly associated with survival.However, the SNP rs1421 did not show any significant effect on patient prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

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Kaplan–Meier plots of non-small-cell lung cancer (NSCLC) patients with different genotypes of rs1126497 in the EpCAM gene. (a) Overall survival of NSCLC patients by rs1126497 using additive genetic model. (b) Overall survival of NSCLC patients by rs1126497 using dominant genetic model. (c) Recurrence-free survival of NSCLC patients by rs1126497 using additive genetic model. (d) Recurrence-free survival of NSCLC patients by rs1126497 using dominant genetic model.
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fig01: Kaplan–Meier plots of non-small-cell lung cancer (NSCLC) patients with different genotypes of rs1126497 in the EpCAM gene. (a) Overall survival of NSCLC patients by rs1126497 using additive genetic model. (b) Overall survival of NSCLC patients by rs1126497 using dominant genetic model. (c) Recurrence-free survival of NSCLC patients by rs1126497 using additive genetic model. (d) Recurrence-free survival of NSCLC patients by rs1126497 using dominant genetic model.

Mentions: The Multivariate Cox regression model was used to evaluate the effect of EpCAM SNPs on death and recurrence in NSCLC patients. As shown in Table2, patients carrying CT or TT genotypes in the SNP rs1126497 showed a significantly higher death risk when compared with those carrying the CC genotype (HR for additive model = 1.46; 95% CI, 1.09–1.97, P = 0.012; HR for dominant model = 1.41; 95% CI, 1.02–1.94, P = 0.039). Similar results were observed in the RFS analysis (HR for additive model = 1.37; 95% CI, 1.06–1.76, P = 0.016; HR for dominant model = 1.34; 95% CI, 1.01–1.77, P = 0.039). Additionally, there were no significant results observed for the SNP rs1421 in either the OS or RFS analyses. For rs1126497, Kaplan–Meier curves significantly distinguished the patient groups with different genotypes in the OS analysis (log–rank P for additive and dominant models = 0.007 and 0.021, respectively) and RFS analysis (log–rank P for additive and dominant models = 0.008 and 0.006, respectively) (Fig.1).


Polymorphisms of EpCAM gene and prognosis for non-small-cell lung cancer in Han Chinese.

Yang Y, Fei F, Song Y, Li X, Zhang Z, Fei Z, Su H, Wan S - Cancer Sci. (2013)

Kaplan–Meier plots of non-small-cell lung cancer (NSCLC) patients with different genotypes of rs1126497 in the EpCAM gene. (a) Overall survival of NSCLC patients by rs1126497 using additive genetic model. (b) Overall survival of NSCLC patients by rs1126497 using dominant genetic model. (c) Recurrence-free survival of NSCLC patients by rs1126497 using additive genetic model. (d) Recurrence-free survival of NSCLC patients by rs1126497 using dominant genetic model.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4317886&req=5

fig01: Kaplan–Meier plots of non-small-cell lung cancer (NSCLC) patients with different genotypes of rs1126497 in the EpCAM gene. (a) Overall survival of NSCLC patients by rs1126497 using additive genetic model. (b) Overall survival of NSCLC patients by rs1126497 using dominant genetic model. (c) Recurrence-free survival of NSCLC patients by rs1126497 using additive genetic model. (d) Recurrence-free survival of NSCLC patients by rs1126497 using dominant genetic model.
Mentions: The Multivariate Cox regression model was used to evaluate the effect of EpCAM SNPs on death and recurrence in NSCLC patients. As shown in Table2, patients carrying CT or TT genotypes in the SNP rs1126497 showed a significantly higher death risk when compared with those carrying the CC genotype (HR for additive model = 1.46; 95% CI, 1.09–1.97, P = 0.012; HR for dominant model = 1.41; 95% CI, 1.02–1.94, P = 0.039). Similar results were observed in the RFS analysis (HR for additive model = 1.37; 95% CI, 1.06–1.76, P = 0.016; HR for dominant model = 1.34; 95% CI, 1.01–1.77, P = 0.039). Additionally, there were no significant results observed for the SNP rs1421 in either the OS or RFS analyses. For rs1126497, Kaplan–Meier curves significantly distinguished the patient groups with different genotypes in the OS analysis (log–rank P for additive and dominant models = 0.007 and 0.021, respectively) and RFS analysis (log–rank P for additive and dominant models = 0.008 and 0.006, respectively) (Fig.1).

Bottom Line: The epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide variety of human cancers and is associated with patient prognosis, including those with lung cancer.We found that the non-synonymous SNP rs1126497 was significantly associated with survival.However, the SNP rs1421 did not show any significant effect on patient prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Show MeSH
Related in: MedlinePlus