Polymorphisms of EpCAM gene and prognosis for non-small-cell lung cancer in Han Chinese.
Bottom Line: We found that the non-synonymous SNP rs1126497 was significantly associated with survival.However, the SNP rs1421 did not show any significant effect on patient prognosis.Instead, the AG+GG genotype in rs1421 was significantly associated with early T stages (T1/T2) when compared with the AA genotype (odds ratio for late stage = 0.65; 95% CI, 0.44-0.96, P = 0.029).
Affiliation: Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.Show MeSH
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Mentions: The Multivariate Cox regression model was used to evaluate the effect of EpCAM SNPs on death and recurrence in NSCLC patients. As shown in Table2, patients carrying CT or TT genotypes in the SNP rs1126497 showed a significantly higher death risk when compared with those carrying the CC genotype (HR for additive model = 1.46; 95% CI, 1.09–1.97, P = 0.012; HR for dominant model = 1.41; 95% CI, 1.02–1.94, P = 0.039). Similar results were observed in the RFS analysis (HR for additive model = 1.37; 95% CI, 1.06–1.76, P = 0.016; HR for dominant model = 1.34; 95% CI, 1.01–1.77, P = 0.039). Additionally, there were no significant results observed for the SNP rs1421 in either the OS or RFS analyses. For rs1126497, Kaplan–Meier curves significantly distinguished the patient groups with different genotypes in the OS analysis (log–rank P for additive and dominant models = 0.007 and 0.021, respectively) and RFS analysis (log–rank P for additive and dominant models = 0.008 and 0.006, respectively) (Fig.1).
Affiliation: Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.