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CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.

Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J, Han W - Cancer Sci. (2013)

Bottom Line: Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells (P < 0.001).In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3 (P < 0.001).We further showed that the expression of MMP2 and the phosphorylation of Erk1/2 were decreased when CMTM3 was restored.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Beijing, China; Key Laboratory of Medical Immunology, Ministry of Health, Beijing, China.

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(a) Immunohistochemical staining showing the relationship between CMTM3 expression and gastric cancer by representative images (magnification, ×100 [left] and ×400 [right]). (b) Kaplan–Meier survival curve showing the association between CMTM3 expression and patients' survival. CMTM3+, CMTM3 positive; CMTM3−, CMTM3 negative; n, number of patients.
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fig04: (a) Immunohistochemical staining showing the relationship between CMTM3 expression and gastric cancer by representative images (magnification, ×100 [left] and ×400 [right]). (b) Kaplan–Meier survival curve showing the association between CMTM3 expression and patients' survival. CMTM3+, CMTM3 positive; CMTM3−, CMTM3 negative; n, number of patients.

Mentions: Next we aimed to examine whether CMTM3 had any clinical significance in gastric cancer. CMTM3 expression was detected in 350 gastric cancer samples and 222 normal gastric tissues by immunochemistry staining. The intensity of CMTM3 staining was remarkably weaker in primary gastric tissues than in normal mucosae (41.43% vs. 59.91%, P = 0.008). Its expression could also be observed significantly more frequently in patients with high grade well-differentiated tumor (Fig.4a).


CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.

Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J, Han W - Cancer Sci. (2013)

(a) Immunohistochemical staining showing the relationship between CMTM3 expression and gastric cancer by representative images (magnification, ×100 [left] and ×400 [right]). (b) Kaplan–Meier survival curve showing the association between CMTM3 expression and patients' survival. CMTM3+, CMTM3 positive; CMTM3−, CMTM3 negative; n, number of patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317871&req=5

fig04: (a) Immunohistochemical staining showing the relationship between CMTM3 expression and gastric cancer by representative images (magnification, ×100 [left] and ×400 [right]). (b) Kaplan–Meier survival curve showing the association between CMTM3 expression and patients' survival. CMTM3+, CMTM3 positive; CMTM3−, CMTM3 negative; n, number of patients.
Mentions: Next we aimed to examine whether CMTM3 had any clinical significance in gastric cancer. CMTM3 expression was detected in 350 gastric cancer samples and 222 normal gastric tissues by immunochemistry staining. The intensity of CMTM3 staining was remarkably weaker in primary gastric tissues than in normal mucosae (41.43% vs. 59.91%, P = 0.008). Its expression could also be observed significantly more frequently in patients with high grade well-differentiated tumor (Fig.4a).

Bottom Line: Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells (P < 0.001).In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3 (P < 0.001).We further showed that the expression of MMP2 and the phosphorylation of Erk1/2 were decreased when CMTM3 was restored.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Beijing, China; Key Laboratory of Medical Immunology, Ministry of Health, Beijing, China.

Show MeSH
Related in: MedlinePlus