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Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.

Shiratsu K, Higuchi K, Nakayama J - Cancer Sci. (2013)

Bottom Line: Loss of αGlcNAc was also significantly associated with poorer patient prognosis in MUC6-positive differentiated-type adenocarcinoma.In undifferentiated-type adenocarcinoma, we observed no significant correlation between mucin phenotypic marker expression, including MUC6, and any clinicopathologic variable.These results together indicate that loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated, but not undifferentiated, types of gastric adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan.

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Related in: MedlinePlus

Expression of MUC6 and α1,4-linked N-acetylglucosamine (αGlcNAc) by gastric cancer cells in intramucosal and invasive regions of tumors. In tumor (a), cancer cells were restricted to the gastric mucosa; in tumors (b) and (c), cancer cells invaded beyond the muscularis mucosae. Tumors (a), (b), and (c) are derived from the same patients’ tumors (a), (b), and (d) shown in Figure1, respectively. Scale bar = 200 μm.
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fig04: Expression of MUC6 and α1,4-linked N-acetylglucosamine (αGlcNAc) by gastric cancer cells in intramucosal and invasive regions of tumors. In tumor (a), cancer cells were restricted to the gastric mucosa; in tumors (b) and (c), cancer cells invaded beyond the muscularis mucosae. Tumors (a), (b), and (c) are derived from the same patients’ tumors (a), (b), and (d) shown in Figure1, respectively. Scale bar = 200 μm.

Mentions: Expression of αGlcNAc in gastric cancer was heterogeneous, irrespective of the histological types. As shown previously,25,32 and further confirmed here, αGlcNAc-positive cancer cells tended to be located in the lower layer of the gastric mucosa rather than in the upper layer, regardless of differentiated or undifferentiated types (Fig.4a,c). Once the cancer cells invaded beyond the muscularis mucosae, αGlcNAc-positive cancer cells were irregularly distributed throughout carcinoma tissues, and the expression levels of αGlcNAc in the invasive region tended to mirror the expression levels of the glycan in the intramucosal cancer region within the same tumor (Fig.4b,c).


Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.

Shiratsu K, Higuchi K, Nakayama J - Cancer Sci. (2013)

Expression of MUC6 and α1,4-linked N-acetylglucosamine (αGlcNAc) by gastric cancer cells in intramucosal and invasive regions of tumors. In tumor (a), cancer cells were restricted to the gastric mucosa; in tumors (b) and (c), cancer cells invaded beyond the muscularis mucosae. Tumors (a), (b), and (c) are derived from the same patients’ tumors (a), (b), and (d) shown in Figure1, respectively. Scale bar = 200 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317868&req=5

fig04: Expression of MUC6 and α1,4-linked N-acetylglucosamine (αGlcNAc) by gastric cancer cells in intramucosal and invasive regions of tumors. In tumor (a), cancer cells were restricted to the gastric mucosa; in tumors (b) and (c), cancer cells invaded beyond the muscularis mucosae. Tumors (a), (b), and (c) are derived from the same patients’ tumors (a), (b), and (d) shown in Figure1, respectively. Scale bar = 200 μm.
Mentions: Expression of αGlcNAc in gastric cancer was heterogeneous, irrespective of the histological types. As shown previously,25,32 and further confirmed here, αGlcNAc-positive cancer cells tended to be located in the lower layer of the gastric mucosa rather than in the upper layer, regardless of differentiated or undifferentiated types (Fig.4a,c). Once the cancer cells invaded beyond the muscularis mucosae, αGlcNAc-positive cancer cells were irregularly distributed throughout carcinoma tissues, and the expression levels of αGlcNAc in the invasive region tended to mirror the expression levels of the glycan in the intramucosal cancer region within the same tumor (Fig.4b,c).

Bottom Line: Loss of αGlcNAc was also significantly associated with poorer patient prognosis in MUC6-positive differentiated-type adenocarcinoma.In undifferentiated-type adenocarcinoma, we observed no significant correlation between mucin phenotypic marker expression, including MUC6, and any clinicopathologic variable.These results together indicate that loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated, but not undifferentiated, types of gastric adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan.

Show MeSH
Related in: MedlinePlus