Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.
Bottom Line: Loss of αGlcNAc was also significantly associated with poorer patient prognosis in MUC6-positive differentiated-type adenocarcinoma.In undifferentiated-type adenocarcinoma, we observed no significant correlation between mucin phenotypic marker expression, including MUC6, and any clinicopathologic variable.These results together indicate that loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated, but not undifferentiated, types of gastric adenocarcinoma.
Affiliation: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan.Show MeSH
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Mentions: Expression of MUC6 was significantly correlated with depth of invasion, lymph node metastasis, stage, lymphatic invasion, venous invasion, and tumor size (Table1). In addition, MUC2 expression was significantly correlated with venous invasion. However, no significant correlation was seen between MUC5AC or CD10 expression and any variable analyzed. Also, expression of individual mucin phenotypic markers was not associated with 5-year cancer-specific survival rates in patients with differentiated-type adenocarcinoma (Fig.2).
Affiliation: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan.