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Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.

Shiratsu K, Higuchi K, Nakayama J - Cancer Sci. (2013)

Bottom Line: Loss of αGlcNAc was also significantly associated with poorer patient prognosis in MUC6-positive differentiated-type adenocarcinoma.In undifferentiated-type adenocarcinoma, we observed no significant correlation between mucin phenotypic marker expression, including MUC6, and any clinicopathologic variable.These results together indicate that loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated, but not undifferentiated, types of gastric adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan.

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Cancer-specific survival in 101 patients with differentiated-type carcinoma based on phenotypic marker expression: (a) MUC5AC, (b) MUC6, (c) MUC2, and (d) CD10. For each marker, there was no significant difference between survival rates of patients whose tumors were positive or negative for the marker (MUC5AC, P = 0.303; MUC6, P = 0.307; MUC2, P = 0.387; and CD10, P = 0.470).
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fig02: Cancer-specific survival in 101 patients with differentiated-type carcinoma based on phenotypic marker expression: (a) MUC5AC, (b) MUC6, (c) MUC2, and (d) CD10. For each marker, there was no significant difference between survival rates of patients whose tumors were positive or negative for the marker (MUC5AC, P = 0.303; MUC6, P = 0.307; MUC2, P = 0.387; and CD10, P = 0.470).

Mentions: Expression of MUC6 was significantly correlated with depth of invasion, lymph node metastasis, stage, lymphatic invasion, venous invasion, and tumor size (Table1). In addition, MUC2 expression was significantly correlated with venous invasion. However, no significant correlation was seen between MUC5AC or CD10 expression and any variable analyzed. Also, expression of individual mucin phenotypic markers was not associated with 5-year cancer-specific survival rates in patients with differentiated-type adenocarcinoma (Fig.2).


Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.

Shiratsu K, Higuchi K, Nakayama J - Cancer Sci. (2013)

Cancer-specific survival in 101 patients with differentiated-type carcinoma based on phenotypic marker expression: (a) MUC5AC, (b) MUC6, (c) MUC2, and (d) CD10. For each marker, there was no significant difference between survival rates of patients whose tumors were positive or negative for the marker (MUC5AC, P = 0.303; MUC6, P = 0.307; MUC2, P = 0.387; and CD10, P = 0.470).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317868&req=5

fig02: Cancer-specific survival in 101 patients with differentiated-type carcinoma based on phenotypic marker expression: (a) MUC5AC, (b) MUC6, (c) MUC2, and (d) CD10. For each marker, there was no significant difference between survival rates of patients whose tumors were positive or negative for the marker (MUC5AC, P = 0.303; MUC6, P = 0.307; MUC2, P = 0.387; and CD10, P = 0.470).
Mentions: Expression of MUC6 was significantly correlated with depth of invasion, lymph node metastasis, stage, lymphatic invasion, venous invasion, and tumor size (Table1). In addition, MUC2 expression was significantly correlated with venous invasion. However, no significant correlation was seen between MUC5AC or CD10 expression and any variable analyzed. Also, expression of individual mucin phenotypic markers was not associated with 5-year cancer-specific survival rates in patients with differentiated-type adenocarcinoma (Fig.2).

Bottom Line: Loss of αGlcNAc was also significantly associated with poorer patient prognosis in MUC6-positive differentiated-type adenocarcinoma.In undifferentiated-type adenocarcinoma, we observed no significant correlation between mucin phenotypic marker expression, including MUC6, and any clinicopathologic variable.These results together indicate that loss of αGlcNAc in MUC6-positive cancer cells is associated with progression and poor prognosis in differentiated, but not undifferentiated, types of gastric adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Japan.

Show MeSH
Related in: MedlinePlus