Clinical impact of c-MET expression and genetic mutational status in colorectal cancer patients after liver resection.
Bottom Line: High levels of c-MET expression (c-MET-high) in the primary tumors were observed in 52% of patients.Relapse-free survival was significantly shorter for patients with c-MET-high primary tumors (9.7 months) than for those with c-MET-low primary tumors (21.1 months) (P = 0.013).These results suggest that a high level of genetic concordance in KRAS, BRAF and PIK3CA between primary tumors and liver metastases, and c-MET-high in the primary tumors were associated with shorter relapse-free survival after hepatic metastasectomy.
Affiliation: Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.Show MeSH
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Mentions: c-MET expression was assessed by IHC in primary tumors and liver metastases expression in all 108 specimens. c-MET staining intensity in the primary tumors was 3 in 7 cases (6%), 2 in 49 cases (45.8%), 1 in 51 cases (47.2%) and negative in 1 case (0.9%). c-MET staining intensity in the liver metastases was 3 in 4 cases (3.7%), 2 in 55 cases (51.9%), 1 in 45 cases (41.7%) and negative in four cases (3.7%) (Fig. 1).
Affiliation: Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.