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Low-grade prostate cancer diverges early from high grade and metastatic disease.

VanderWeele DJ, Brown CD, Taxy JB, Gillard M, Hatcher DM, Tom WR, Stadler WM, White KP - Cancer Sci. (2014)

Bottom Line: Notably, mutations in cancer-associated genes and the p53 signaling pathway were found exclusively in high-grade foci and metastases.The pattern of mutations is consistent with early divergence between low- and high-grade foci and late divergence between high-grade foci and metastases.These data provide insights into the development of high-grade and metastatic prostate cancer.

View Article: PubMed Central - PubMed

Affiliation: Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA; Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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ERG expression. Immunohistochemical analysis for ERG in coincident foci from PrCa 6 and PrCa 18.
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fig04: ERG expression. Immunohistochemical analysis for ERG in coincident foci from PrCa 6 and PrCa 18.

Mentions: Rearrangements involving ERG are the most common genetic derangement in prostate cancer and are thought to occur early in tumorigenesis. These events are not typically captured by exome sequencing. Therefore we performed IHC for ERG to look for overexpression, which is typically restricted to cells harboring an ERG rearrangement. Of the two specimens exhibiting positive ERG staining, PrCa 6 showed consistently positive staining in all tumor foci (Fig. 4). In contrast, in PrCa 18 the low-grade focus was negative, the high-grade focus was equivocal with few cells positive for ERG and the metastatic focus was more widely focally positive.


Low-grade prostate cancer diverges early from high grade and metastatic disease.

VanderWeele DJ, Brown CD, Taxy JB, Gillard M, Hatcher DM, Tom WR, Stadler WM, White KP - Cancer Sci. (2014)

ERG expression. Immunohistochemical analysis for ERG in coincident foci from PrCa 6 and PrCa 18.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317857&req=5

fig04: ERG expression. Immunohistochemical analysis for ERG in coincident foci from PrCa 6 and PrCa 18.
Mentions: Rearrangements involving ERG are the most common genetic derangement in prostate cancer and are thought to occur early in tumorigenesis. These events are not typically captured by exome sequencing. Therefore we performed IHC for ERG to look for overexpression, which is typically restricted to cells harboring an ERG rearrangement. Of the two specimens exhibiting positive ERG staining, PrCa 6 showed consistently positive staining in all tumor foci (Fig. 4). In contrast, in PrCa 18 the low-grade focus was negative, the high-grade focus was equivocal with few cells positive for ERG and the metastatic focus was more widely focally positive.

Bottom Line: Notably, mutations in cancer-associated genes and the p53 signaling pathway were found exclusively in high-grade foci and metastases.The pattern of mutations is consistent with early divergence between low- and high-grade foci and late divergence between high-grade foci and metastases.These data provide insights into the development of high-grade and metastatic prostate cancer.

View Article: PubMed Central - PubMed

Affiliation: Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA; Department of Medicine, University of Chicago, Chicago, Illinois, USA.

Show MeSH
Related in: MedlinePlus