Meta-analysis comparing higher and lower dose radiotherapy for palliation in locally advanced lung cancer.
Bottom Line: The combined odds ratios (ORs) indicated no significant difference in palliation of cough, chest pain, and hemoptysis between the higher dose and lower dose RT groups (combined ORs = 0.88, 1.83, 1.39, respectively).The 1- and 2-year OS rates were similar between the high and low dose RT groups (combined ORs = 1.09 and 1.38, respectively).This meta-analysis indicates that high dose (≥30 Gy) and lower dose (<30 Gy) RT provide similar symptom palliation and 1- and 2-year OS in patients with locally advanced lung cancer.
Affiliation: Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.Show MeSH
Related in: MedlinePlus
Mentions: A total of five studies(13)– (17) met the inclusion criteria, and were included in this analysis. A flow diagram of the study selection is shown in Figure 1. The basic characteristics of the studies included in the meta-analysis are summarized in Table 1. Among the five studies included, there were two equivalent and three non-inferior randomized controlled trials. A total 1730 patients with non-small cell lung cancer were enrolled in the five studies, consisting of 925 treated with a higher RT dose (≥30 Gy) and 805 treated with a lower RT dose (<30 Gy). The total number of patients in each of the studies ranged from 148 to 509. For patients treated with a higher RT dose, palliation of cough ranged from 49% to 58%, palliation of chest pain from 64% to 86%, and palliation of hemoptysis from 80% to 97%; for patients treated with a lower RT dose, palliation of cough ranged from 47% to 65%, palliation of chest pain from 50% to 81%, and palliation of hemoptysis from 75% to 95%. For patients treated with higher dose RT, 1-year OS ranged from 11% to 36%, and 2-year OS ranged from 8% to 12%; for patients treated with lower dose RT, 1- and 2-year OS ranged from 19% to 29% and 4% to 9%, respectively.
Affiliation: Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.