Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.
Bottom Line: In contrast, protocadherin gamma subfamily genes were upregulated in DFL and NFL.Double immunofluorescence studies revealed that CCL20 and CCR6 were co-expressed in both DFL and MALT.We hypothesize that increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis.
Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.Show MeSH
Related in: MedlinePlus
Mentions: Immunohistochemical studies revealed that CCL20 protein expression was significantly higher in DFL and MALT samples than in NFL samples (P < 0.001). CCL20 was positive in 97% (31/32) of DFL samples and 89% (17/19) of MALT samples, but only 4% (1/27) of NFL samples (Fig.4c–e). MAdCAM-1 expression, present in vascular endothelial cells, was more frequently expressed in DFL (28/32, 88%) and MALT (18/19, 95%) samples than in NFL samples (5/27, 19%; Fig.4f–h). This difference was also statistically significant (P < 0.001). In contrast, the expression of PCDHGA8, A3 and B4 was significantly higher in DFL and NFL than in MALT (Fig.5a–i). A summary of the immunohistochemical results is shown in Table1.
Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.