Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.
Bottom Line: In contrast, protocadherin gamma subfamily genes were upregulated in DFL and NFL.Double immunofluorescence studies revealed that CCL20 and CCR6 were co-expressed in both DFL and MALT.We hypothesize that increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis.
Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.Show MeSH
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Mentions: Among the statistically significant DEG selected and described above, chemokine (C-C motif) ligand 20 (CCL20) and mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) have been reported to be differentially expressed in several cancers,15–20 and, therefore, we focused on these genes in order to validate the expression profiles observed in the microarray analysis. Both CCL20 and MAdCAM-1 were upregulated in DFL and MALT, but downregulated in NFL in this study. We also focused on protocadherin gamma subfamily genes (PCDHGB3, A5, B2, A3, B4, B1, A7, A9, A8, B6, B7, A12 and A2), because these genes represented a prominent gene family in the present study and were upregulated in both DFL and NFL. We created a heatmap using CCL20, MAdCAM-1 and PCDHG family genes and lymphoma-related genes, as shown in Figure3. In this heatmap, we included not only DEG, but also the following non-DEG: IL2RG, ITGB2, MMP25, IL12RB1, TNFAIP8L2, TNFRSF8, ILDR2, CXCL10 and C3.
Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.