Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.
Bottom Line: In contrast, protocadherin gamma subfamily genes were upregulated in DFL and NFL.Double immunofluorescence studies revealed that CCL20 and CCR6 were co-expressed in both DFL and MALT.We hypothesize that increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis.
Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.Show MeSH
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Mentions: A hierarchical sample clustering using 2918 DEG showed that the three lymphoma types (DFL, MALT and NFL) and the normal control tissues (NDU and STCH) were divided into two branches, while the control disease tissues (RLH) belonged to the former branch (Fig.1). Nine of 10 DFL and 8 of 10 MALT clustered in the same branch, indicating that DFL and MALT were more closely related than DFL and NFL. A heatmap of the 2918 DEG is shown in Supplementary Figure S2.
Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.