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Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.

Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Maeda Y, Goto N, Araki H, Harada M, Ando M, Iwamuro M, Tanimoto M, Yamamoto K, Gascoyne RD, Yoshino T - Cancer Sci. (2014)

Bottom Line: In contrast, protocadherin gamma subfamily genes were upregulated in DFL and NFL.Double immunofluorescence studies revealed that CCL20 and CCR6 were co-expressed in both DFL and MALT.We hypothesize that increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

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Related in: MedlinePlus

Hierarchical sample clustering was conducted using the 2918 differentially expressed genes (see Fig. S2). Although a few exceptions were observed, normal tissues (normal duodenal mucosa [NDU] and normal gastric mucosa [STCH]) were clustered together as one group, and the other group included lymphomas (duodenal follicular lymphoma [DFL], MALT and nodal follicular lymphoma [NFL]) and control disease samples (reactive lymphoid hyperplasia [RLH]). Clustering was conducted using MultiExperiment Viewer (MeV) version 4.8.1. The cluster for NFL is shown in red, RLH is in green, DFL is in blue, and MALT is in yellow. A clustering of the 2918 genes is shown in Supplementary Figure S3.
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fig01: Hierarchical sample clustering was conducted using the 2918 differentially expressed genes (see Fig. S2). Although a few exceptions were observed, normal tissues (normal duodenal mucosa [NDU] and normal gastric mucosa [STCH]) were clustered together as one group, and the other group included lymphomas (duodenal follicular lymphoma [DFL], MALT and nodal follicular lymphoma [NFL]) and control disease samples (reactive lymphoid hyperplasia [RLH]). Clustering was conducted using MultiExperiment Viewer (MeV) version 4.8.1. The cluster for NFL is shown in red, RLH is in green, DFL is in blue, and MALT is in yellow. A clustering of the 2918 genes is shown in Supplementary Figure S3.

Mentions: A hierarchical sample clustering using 2918 DEG showed that the three lymphoma types (DFL, MALT and NFL) and the normal control tissues (NDU and STCH) were divided into two branches, while the control disease tissues (RLH) belonged to the former branch (Fig.1). Nine of 10 DFL and 8 of 10 MALT clustered in the same branch, indicating that DFL and MALT were more closely related than DFL and NFL. A heatmap of the 2918 DEG is shown in Supplementary Figure S2.


Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.

Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Maeda Y, Goto N, Araki H, Harada M, Ando M, Iwamuro M, Tanimoto M, Yamamoto K, Gascoyne RD, Yoshino T - Cancer Sci. (2014)

Hierarchical sample clustering was conducted using the 2918 differentially expressed genes (see Fig. S2). Although a few exceptions were observed, normal tissues (normal duodenal mucosa [NDU] and normal gastric mucosa [STCH]) were clustered together as one group, and the other group included lymphomas (duodenal follicular lymphoma [DFL], MALT and nodal follicular lymphoma [NFL]) and control disease samples (reactive lymphoid hyperplasia [RLH]). Clustering was conducted using MultiExperiment Viewer (MeV) version 4.8.1. The cluster for NFL is shown in red, RLH is in green, DFL is in blue, and MALT is in yellow. A clustering of the 2918 genes is shown in Supplementary Figure S3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317842&req=5

fig01: Hierarchical sample clustering was conducted using the 2918 differentially expressed genes (see Fig. S2). Although a few exceptions were observed, normal tissues (normal duodenal mucosa [NDU] and normal gastric mucosa [STCH]) were clustered together as one group, and the other group included lymphomas (duodenal follicular lymphoma [DFL], MALT and nodal follicular lymphoma [NFL]) and control disease samples (reactive lymphoid hyperplasia [RLH]). Clustering was conducted using MultiExperiment Viewer (MeV) version 4.8.1. The cluster for NFL is shown in red, RLH is in green, DFL is in blue, and MALT is in yellow. A clustering of the 2918 genes is shown in Supplementary Figure S3.
Mentions: A hierarchical sample clustering using 2918 DEG showed that the three lymphoma types (DFL, MALT and NFL) and the normal control tissues (NDU and STCH) were divided into two branches, while the control disease tissues (RLH) belonged to the former branch (Fig.1). Nine of 10 DFL and 8 of 10 MALT clustered in the same branch, indicating that DFL and MALT were more closely related than DFL and NFL. A heatmap of the 2918 DEG is shown in Supplementary Figure S2.

Bottom Line: In contrast, protocadherin gamma subfamily genes were upregulated in DFL and NFL.Double immunofluorescence studies revealed that CCL20 and CCR6 were co-expressed in both DFL and MALT.We hypothesize that increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Show MeSH
Related in: MedlinePlus