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Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ.

Osako T, Iwase T, Ushijima M, Horii R, Fukami Y, Kimura K, Matsuura M, Akiyama F - Cancer Sci. (2014)

Bottom Line: Of the 113 patients with invasive disease, 4 (3.5%) and 9 (8.0%) had macro- and micrometastasis.Predictors of invasive disease included palpability, mammographic mass, and calcifications (spread >20 mm), and intraductal solid structure, but no predictor was found for SN metastasis.Therefore, even though occult invasive disease was found at final pathology, most of the patients had no metastasis or only micrometastasis in axillary nodes.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

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Distribution of pathological T status on final pathology (a) and overall pathological N status (b) in patients with a preoperative needle-biopsy diagnosis of ductal carcinoma in situ. is, in situ (intraductal carcinoma lesion); mi, micrometastasis; sn, sentinel node.
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fig02: Distribution of pathological T status on final pathology (a) and overall pathological N status (b) in patients with a preoperative needle-biopsy diagnosis of ductal carcinoma in situ. is, in situ (intraductal carcinoma lesion); mi, micrometastasis; sn, sentinel node.

Mentions: Of the 336 patients, 223 (66.4%) did not have an invasive lesion (pTis) on final pathology and 113 (33.6%) were upstaged to invasive disease (pT1/T2) (Fig.2a). Of the 113 patients, 85 (75.2%) had an invasive lesion ≤5 mm in size (pT1mi/T1a).


Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ.

Osako T, Iwase T, Ushijima M, Horii R, Fukami Y, Kimura K, Matsuura M, Akiyama F - Cancer Sci. (2014)

Distribution of pathological T status on final pathology (a) and overall pathological N status (b) in patients with a preoperative needle-biopsy diagnosis of ductal carcinoma in situ. is, in situ (intraductal carcinoma lesion); mi, micrometastasis; sn, sentinel node.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317837&req=5

fig02: Distribution of pathological T status on final pathology (a) and overall pathological N status (b) in patients with a preoperative needle-biopsy diagnosis of ductal carcinoma in situ. is, in situ (intraductal carcinoma lesion); mi, micrometastasis; sn, sentinel node.
Mentions: Of the 336 patients, 223 (66.4%) did not have an invasive lesion (pTis) on final pathology and 113 (33.6%) were upstaged to invasive disease (pT1/T2) (Fig.2a). Of the 113 patients, 85 (75.2%) had an invasive lesion ≤5 mm in size (pT1mi/T1a).

Bottom Line: Of the 113 patients with invasive disease, 4 (3.5%) and 9 (8.0%) had macro- and micrometastasis.Predictors of invasive disease included palpability, mammographic mass, and calcifications (spread >20 mm), and intraductal solid structure, but no predictor was found for SN metastasis.Therefore, even though occult invasive disease was found at final pathology, most of the patients had no metastasis or only micrometastasis in axillary nodes.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Show MeSH
Related in: MedlinePlus