Antitumor effect of fibrin glue containing temozolomide against malignant glioma.
Bottom Line: Our high-power liquid chromatography studies indicated that FG containing TMZ (TMZ-FG) manifested a sustained drug release potential.In both phases, TMZ-FG failed to severely damage normal brain tissue.TMZ-FG may represent a safe new drug delivery system with sustained drug release potential to treat malignant glioma.
Affiliation: Department of Neurosurgery, Kumamoto University Graduate School of Medical Science, Honjo, Chuo-ku, Kumamoto, Japan.Show MeSH
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Mentions: At the end of the observation period the relative TV was significantly smaller in all TMZ-treated than TMZ-untreated mice (Fig.3a). Among the groups treated with TMZ, the TV in group 6 (TMZ-FGS plus peroral TMZ) was smaller than in the other two groups; the difference in the relative TV was significant in mice transplanted with U87MG cells (Fig.3b). The TV in group 3 (TMZ-FGS) was smaller than in group 5 (peroral TMZ) but the different was not statistically significant. There was no significant difference in the relative TV among the TMZ-untreated groups (Fig.3a,c; Table S1).
Affiliation: Department of Neurosurgery, Kumamoto University Graduate School of Medical Science, Honjo, Chuo-ku, Kumamoto, Japan.