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Antitumor effect of fibrin glue containing temozolomide against malignant glioma.

Anai S, Hide T, Takezaki T, Kuroda J, Shinojima N, Makino K, Nakamura H, Yano S, Kuratsu J - Cancer Sci. (2014)

Bottom Line: Our high-power liquid chromatography studies indicated that FG containing TMZ (TMZ-FG) manifested a sustained drug release potential.In both phases, TMZ-FG failed to severely damage normal brain tissue.TMZ-FG may represent a safe new drug delivery system with sustained drug release potential to treat malignant glioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Kumamoto University Graduate School of Medical Science, Honjo, Chuo-ku, Kumamoto, Japan.

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Related in: MedlinePlus

Growth curve and plots of the relative subcutaneous tumor volume. (●), Sham (group 1); (□), fibrin glue sheets (FGS) without temozolomide (TMZ) (FGS; group 2); (○), FGS containing TMZ (TMZ-FGS; group 3); (△), distilled water perorally (DW-PO; group 4); (♦), TMZ perorally (TMZ-PO; group 5); (×), TMZ-FGS plus TMZ perorally (TMZ-FGS-PO; group 6). (a) Growth curve (n = 6). (▽), FGS placement; (↓), oral administration of TMZ or distilled water; (▼), killed. (b) Plots of relative tumor volume in the three different TMZ-treated groups at the time the mice were killed (n = 6). Data were analyzed using anova. A P < 0.05 was considered statistically significant. *P < 0.05. **P < 0.001. (c) Images of mice bearing subcutaneous tumors induced with U87MG cells and the tumors removed at the time the mice were killed.
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fig03: Growth curve and plots of the relative subcutaneous tumor volume. (●), Sham (group 1); (□), fibrin glue sheets (FGS) without temozolomide (TMZ) (FGS; group 2); (○), FGS containing TMZ (TMZ-FGS; group 3); (△), distilled water perorally (DW-PO; group 4); (♦), TMZ perorally (TMZ-PO; group 5); (×), TMZ-FGS plus TMZ perorally (TMZ-FGS-PO; group 6). (a) Growth curve (n = 6). (▽), FGS placement; (↓), oral administration of TMZ or distilled water; (▼), killed. (b) Plots of relative tumor volume in the three different TMZ-treated groups at the time the mice were killed (n = 6). Data were analyzed using anova. A P < 0.05 was considered statistically significant. *P < 0.05. **P < 0.001. (c) Images of mice bearing subcutaneous tumors induced with U87MG cells and the tumors removed at the time the mice were killed.

Mentions: At the end of the observation period the relative TV was significantly smaller in all TMZ-treated than TMZ-untreated mice (Fig.3a). Among the groups treated with TMZ, the TV in group 6 (TMZ-FGS plus peroral TMZ) was smaller than in the other two groups; the difference in the relative TV was significant in mice transplanted with U87MG cells (Fig.3b). The TV in group 3 (TMZ-FGS) was smaller than in group 5 (peroral TMZ) but the different was not statistically significant. There was no significant difference in the relative TV among the TMZ-untreated groups (Fig.3a,c; Table S1).


Antitumor effect of fibrin glue containing temozolomide against malignant glioma.

Anai S, Hide T, Takezaki T, Kuroda J, Shinojima N, Makino K, Nakamura H, Yano S, Kuratsu J - Cancer Sci. (2014)

Growth curve and plots of the relative subcutaneous tumor volume. (●), Sham (group 1); (□), fibrin glue sheets (FGS) without temozolomide (TMZ) (FGS; group 2); (○), FGS containing TMZ (TMZ-FGS; group 3); (△), distilled water perorally (DW-PO; group 4); (♦), TMZ perorally (TMZ-PO; group 5); (×), TMZ-FGS plus TMZ perorally (TMZ-FGS-PO; group 6). (a) Growth curve (n = 6). (▽), FGS placement; (↓), oral administration of TMZ or distilled water; (▼), killed. (b) Plots of relative tumor volume in the three different TMZ-treated groups at the time the mice were killed (n = 6). Data were analyzed using anova. A P < 0.05 was considered statistically significant. *P < 0.05. **P < 0.001. (c) Images of mice bearing subcutaneous tumors induced with U87MG cells and the tumors removed at the time the mice were killed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317836&req=5

fig03: Growth curve and plots of the relative subcutaneous tumor volume. (●), Sham (group 1); (□), fibrin glue sheets (FGS) without temozolomide (TMZ) (FGS; group 2); (○), FGS containing TMZ (TMZ-FGS; group 3); (△), distilled water perorally (DW-PO; group 4); (♦), TMZ perorally (TMZ-PO; group 5); (×), TMZ-FGS plus TMZ perorally (TMZ-FGS-PO; group 6). (a) Growth curve (n = 6). (▽), FGS placement; (↓), oral administration of TMZ or distilled water; (▼), killed. (b) Plots of relative tumor volume in the three different TMZ-treated groups at the time the mice were killed (n = 6). Data were analyzed using anova. A P < 0.05 was considered statistically significant. *P < 0.05. **P < 0.001. (c) Images of mice bearing subcutaneous tumors induced with U87MG cells and the tumors removed at the time the mice were killed.
Mentions: At the end of the observation period the relative TV was significantly smaller in all TMZ-treated than TMZ-untreated mice (Fig.3a). Among the groups treated with TMZ, the TV in group 6 (TMZ-FGS plus peroral TMZ) was smaller than in the other two groups; the difference in the relative TV was significant in mice transplanted with U87MG cells (Fig.3b). The TV in group 3 (TMZ-FGS) was smaller than in group 5 (peroral TMZ) but the different was not statistically significant. There was no significant difference in the relative TV among the TMZ-untreated groups (Fig.3a,c; Table S1).

Bottom Line: Our high-power liquid chromatography studies indicated that FG containing TMZ (TMZ-FG) manifested a sustained drug release potential.In both phases, TMZ-FG failed to severely damage normal brain tissue.TMZ-FG may represent a safe new drug delivery system with sustained drug release potential to treat malignant glioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Kumamoto University Graduate School of Medical Science, Honjo, Chuo-ku, Kumamoto, Japan.

Show MeSH
Related in: MedlinePlus