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Antitumor effect of fibrin glue containing temozolomide against malignant glioma.

Anai S, Hide T, Takezaki T, Kuroda J, Shinojima N, Makino K, Nakamura H, Yano S, Kuratsu J - Cancer Sci. (2014)

Bottom Line: Our high-power liquid chromatography studies indicated that FG containing TMZ (TMZ-FG) manifested a sustained drug release potential.In both phases, TMZ-FG failed to severely damage normal brain tissue.TMZ-FG may represent a safe new drug delivery system with sustained drug release potential to treat malignant glioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Kumamoto University Graduate School of Medical Science, Honjo, Chuo-ku, Kumamoto, Japan.

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Dose-dependent effects of temozolomide (TMZ) on the growth of glioma cell lines. (a) Cell proliferation assay (n = 6). (▀), Control; (▵), 0.1 mM TMZ; (⋄), 0.4 mM TMZ; (•), 0.8 mM TMZ; (×), 1 mM TMZ. (b) Morphology of glioma cells incubated for 72 h with 1 mM TMZ and of the controls. Bar, 500 μm. K-GIC, Kumamoto-glioma-initiating cell.
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fig01: Dose-dependent effects of temozolomide (TMZ) on the growth of glioma cell lines. (a) Cell proliferation assay (n = 6). (▀), Control; (▵), 0.1 mM TMZ; (⋄), 0.4 mM TMZ; (•), 0.8 mM TMZ; (×), 1 mM TMZ. (b) Morphology of glioma cells incubated for 72 h with 1 mM TMZ and of the controls. Bar, 500 μm. K-GIC, Kumamoto-glioma-initiating cell.

Mentions: The TMZ inhibited the proliferation of all cell lines in a dose-dependent manner (Fig.1a). At 1 mM TMZ, the glioma cell density and the number of colonies formed by glioma cells were decreased (Fig.1b).


Antitumor effect of fibrin glue containing temozolomide against malignant glioma.

Anai S, Hide T, Takezaki T, Kuroda J, Shinojima N, Makino K, Nakamura H, Yano S, Kuratsu J - Cancer Sci. (2014)

Dose-dependent effects of temozolomide (TMZ) on the growth of glioma cell lines. (a) Cell proliferation assay (n = 6). (▀), Control; (▵), 0.1 mM TMZ; (⋄), 0.4 mM TMZ; (•), 0.8 mM TMZ; (×), 1 mM TMZ. (b) Morphology of glioma cells incubated for 72 h with 1 mM TMZ and of the controls. Bar, 500 μm. K-GIC, Kumamoto-glioma-initiating cell.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317836&req=5

fig01: Dose-dependent effects of temozolomide (TMZ) on the growth of glioma cell lines. (a) Cell proliferation assay (n = 6). (▀), Control; (▵), 0.1 mM TMZ; (⋄), 0.4 mM TMZ; (•), 0.8 mM TMZ; (×), 1 mM TMZ. (b) Morphology of glioma cells incubated for 72 h with 1 mM TMZ and of the controls. Bar, 500 μm. K-GIC, Kumamoto-glioma-initiating cell.
Mentions: The TMZ inhibited the proliferation of all cell lines in a dose-dependent manner (Fig.1a). At 1 mM TMZ, the glioma cell density and the number of colonies formed by glioma cells were decreased (Fig.1b).

Bottom Line: Our high-power liquid chromatography studies indicated that FG containing TMZ (TMZ-FG) manifested a sustained drug release potential.In both phases, TMZ-FG failed to severely damage normal brain tissue.TMZ-FG may represent a safe new drug delivery system with sustained drug release potential to treat malignant glioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Kumamoto University Graduate School of Medical Science, Honjo, Chuo-ku, Kumamoto, Japan.

Show MeSH
Related in: MedlinePlus